AURKA

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AURKA

A gene on chromosome 20q13 that encodes Aurora kinase A, which is involved in regulating many early mitotic events such as entry into mitosis. Aurora A levels rise during the G2 phase and peak early in mitosis. It is highly expressed in the testes, as well as in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
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vitis strain "ARK-1", which was identified in our lab and strongly inhibited tumor formation in grapevine in fields, as a new antagonistic strain.
vitis strains ARK-1, ARK-2, ARK-3, and VAR03-1 were selected as biological control agents against grapevine crown gall.
(23) On grapevine seedlings, a 1 : 1 cell ratio of each strain ARK-1, ARK-2, ARK-3, or VAR03-1 to the mixture of seven different R.
(27) We are interested to clarify the mechanism of control of ARK-1 and why ARK-1 is overwhelmingly powerful in suppressing tumor formation compared with K84 and VAR06-30, and we discuss it in a later section.
Pruned grapevine roots were soaked for 1h in a cell suspension ([10.sup.8] cells/ml) of nonpathogenic strains ARK-1, ARK-2, ARK-3, or VAR03-1.
Thus, we conducted field trials to verify the control effect of strain ARK-1 by root dipping method with nursery stocks of grapevine in several vineyards in Japan.
(23) Roots of plants were soaked for 1 h in a cell suspension of strain ARK-1 ([10.sup.8] cells/ml) or water, and were then planted in each plot.
5, the integrated relative risk was 0.18 (95% confidence interval: 0.10-0.32, p < 0.001), indicating that ARK-1 treatment significantly reduced the disease incidence.
Meta-analysis of the seven field trials showed strong evidence that ARK-1 was effective in controlling grapevine crown gall by application in the field.
In addition to grapevines, we have evidence that ARK-1 can effectively control apple, Japanese pear, peach, rose, and tomato crown gall caused by R.
In order to determine the rate of ARK-1 survival on grapevine roots in the soil, an antibiotic-resistant mutant of ARK-1, ARK-1sc, was developed.
Thus, the result for ARK-1sc indicated that strain ARK-1 not only established populations in the rhizosphere of grapevine but also persisted inside roots for up to 3 years.