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In addition, selected miRNAs could also control DEGs involved in the innate immune response including, for example, NKTR (hsa-miR-181a-5p, -486-5p, -151-3p, and -27b-3p), KIR2DL4 (hsa-miR-146a-5p), STAT1 (hsa-miR584-5p, -27b-3p, -128-3p, and -146a-5p), STAT2 (hsa-miR143-3p), and DEGs belonging to the Toll-like receptor (TLR) pathway such as TLR2, IKBKB, JUN, REL, NAMPT, HSP90B1, HSPA4, and ARF3. In particular, we have to mention that TLR2 (targetedby hsa-miR-143-3p and-146a-5p) is thought to be up-regulated in BD patients [32, 33].
Other DEGs targeted in clusters were involved in TLR signaling including HSPA4, IKBKB, JUN, REL, S100A8, TLR2 (CL1), and ARF3 and NAMPT (CL2).