ARF1


Also found in: Acronyms.

ARF1

A gene on chromosome 1q42 that encodes a protein of the ADP-ribosylation factor gene family, which encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and are involved in vesicular trafficking as phospholipase D activators. ARF1 localises to the Golgi apparatus and has a central role in intra-Golgi transport.
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Human and the corresponding Drosophila gene names Human Drosophila MGAT 1 Mgat1 TPT1 Tctp CALM3 Cam TINP1 Ip259 FEN1 Fen1 HINT1 HINT1 CNN3 Hsc70-3 DEF8 DEF8 IDE Ide Mortalin Hsc70-5 ARF1 Arf79f CFL1 YL-1 PTPRF Liprin-alpha RAP1B Roughened ARHGAP1 RhoGAP68f Ipek Even (1) [iD], Izzet Akiva (1) [iD], Necla Birgul Iyison (1,2) [iD]
Moreover, a recent finding showed that Golgi brefeldin A resistance factor 1 (GBF1), an exchange/activator factor of Arf1, also intervenes in the translocation of ATGL from ER membrane to LD surface [73], though the mechanisms underlying are still poorly understood.
Jackson, "Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1," PLoS One, vol.
"Until now, ARF1 has been associated with harmless albeit important housekeeping duties of cells.
The researchers used invasive breast cancer cell lines to study ARF1's role.
Their findings suggest that EGF works through ARF1 in these cells.
Also, when ARF1 activity was chemically blocked, breast cancer cell migration and growth was reduced.