ZEB1

(redirected from AREB6)

ZEB1

A gene on chromosome 10p11.22 that encodes a zinc finger transcription factor thought to play a role in transcriptional repression of IL-2.

Molecular pathology
ZEB1 mutations are associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy.
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References in periodicals archive ?
Zinc-finger E-box-binding homeobox 1 (ZEB1, also known as dEF1, Nil-2-a, Tcf8, Bzp, Areb6, Meb1, Zfhx1a, and Zfhep) has been identified as a transcriptional factor which could induce epithelial to mesenchymal transition (EMT) [10,11].
A homology search using the Match program (http://www.gene-regulation.com/index.html) revealed that the 5'-untranscribed region (-190 to +1) of the FUT1 gene contained several putative binding sites for transcription factors such as Elk-1, c-Rel, NF-[kappa]B, AREB6, and CREB.