ATP6V0A2

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ATP6V0A2

A gene on chromosome 12q24.31 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.

Molecular pathology
ATP6V0A2 mutations cause cutis laxa type II and wrinkly skin syndrome.
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The CBCT scan of an artificial endodontic training tooth was used in this in-vitro study to allow for comparison with the ARCL instead of using EAL measurements as performed in other studies (14, 17).
The degree of virtual preflaring for each root canal and mean absolute differences [mm] between CBCT measurements with the 3D Endo software and the actual root canal length (ARCL) Type of root canal n Degree of preflaring Mean SD Mesiobuccal 65 14.31 0.26 0.22 Second mesiobuccal 65 31.34 0.46 0.24 Distobuccal 65 16.59 0.32 0.17 Palatal 65 11.42 0.18 0.13 Total 260 0.30 0.22
Hypomyelination is a distinguished characteristic in ARCL [24].
Our study demonstrates that the two site mutations, R119G and R119H, could influence the function of the P5CR1 protein, which could be a pathomechanism for ARCL. Our results highlight the importance of the "charged pocket" in P5CR1 function which could provide a new treatment strategy for ARCL in the future.
1 shows the result of plotting the lag at these positive sighing events versus the arcl of the same.
With the exception of five visual points on the lower left, there seems to be a fairly clear but modest trend of smaller lag sightings becoming enabled by compensatingly larger arcl. There are also two binocular sightings standing off at low lag from the data consensus.
It was notable in some of the report descriptions how the observers at events pushing the lower lag and lower arcl boundaries drew attention to the extreme and, for each individual, unaccustomed level of difficulty at that achieved sighting event.
2 shows the result of taking a closer look at these data and also running some simulations of the lag and the arcl for arbitrary values of the observer latitude.
Turning now to the five exceptional visual sightings at low lag and arcl, marked as "?", is there any way to infer why they are different?
So far we know that visibility is blocked, firstly, at low arcl and, secondly, at low lag for a typical arcl, but what about very large arcl?
To understand the lag and arcl effects better, a simulation was run of all Moon elongation ascent (viz.
For low to moderate latitude (0-35[degrees]), the elongation and descent angles range over all possibilities such that for a small lag, no large arcl is possible, and correspondingly for a small arcl, no large lag is possible.