AIP

(redirected from ARA9)

AIP

(1) A 330 residue protein that helps stabilise the AIP-hsp90-AhR complex and protects the AhR receptor from ubiquitination under heat-stress conditions; AIP may also play a role in regulating the rate of AhR turnover by delaying AhR nuclear translocation after ligand binding.
(2) A gene on chromosome 11q13.3 that encodes a receptor for aryl hydrocarbons and a ligand-activated transcription factor. It resides in the cytoplasm as part of a multiprotein complex and is transported to the nucleus once it binds with a ligand. AIP regulates the expression of many xenobiotic metabolising enzymes; it binds specifically to and inhibits the activity of hepatitis B virus.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

AIP

Acute intermittent porphyria
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In the absence of ligand, the AHR can be found in the cytosol bound to a dimer of the heat shock protein of 90 kDa, Hsp90, and the immunophilin-like protein, AIP (also known as XAP2 and ARA9) [8, 9].
Bradfield, "Characterization of the Ah receptor-associated protein, ARA9," The Journal of Biological Chemistry, vol.