Neuroendocrine carcinoma (NEC) of the head and neck are thought to be derived from the APUD cell
family (amine precursor uptake and decarboxylase system), more specifically the Kulchitsky's cells.
The APUD cell
concept and its implications in pathology.
Those DNES cells secreting serotonin or certain other amine derivatives demonstrate amine precursor uptake and decarboxylation and are often referred to acronymically as APUD cells, e.g.
Review article--involvement of gastric APUD cells in chronic renal failure.
The epithelial cell layers of the anterior intestine were consisted mainly of columnar enterocytes, sac-shaped goblet and a few APUD cells
Enteroendocrine cells are alternatively known as neuroendocrine cells and APUD cells
because they were thought to originate from the neural crest.
Cytochemical identification of human and murine pituitary corticotrophs and somatotrophs as APUD cells
(19-22) Other theory is that SCC of the prostate arises de novo from APUD cells
in the prostate (22), (23) and third theory is that SCC of the prostate arises from stem cells in the prostate.
Identification, localization and morphology of APUD cells
in gastroenteropancreatic system of stomach--containing teleosts.
As early as 1798, Sommering recognized this unique relationship when he referred to the pancreas as the "abdominal salivary gland." (28) Carcinoid tumors are known to derive from the neural crest or neuroendocrine (APUD) tissues, although we are not certain whether APUD cells
are present in normal salivary glands.
Tumors arising from APUD cells
may contain high amounts of NSE detectable by both immunostaining of tumor cells and radioimmunological measurement of extractable enzyme [2, 3].