TAP2

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TAP2

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance and antigen presentation. TAP2 forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.

Molecular pathology
TAP2 mutations have been tentatively linked to ankylosing spondylitis, type-1 diabetes and coeliac disease.
References in periodicals archive ?
Genetica y Genomica de las LPCAsas Localizacion Enzima catabolizante Otros nombres cromosomica LYPLA1 8 (Lysophospholipase I) LYPLAL1 (LYPLA-like Q96AV0 1q41 1) LYPLA2 APT2 1p36.12-p35 (Lisofosfo-lipasa (Acil-protein-thioesterasa), * Pseudogen II) lecitinasa B, lisolecitinasa, en: 6p21.31, phospholipase B.
By April 1996, Smith's group had located and cloned two phosphate transporter genes from Arabidopsis, (APT1 and APT2) and by October 1997 had cloned a sulfate transporter gene, HVST1 from barley.
Cavalcanti-Galdino, Rua Vigolvino Florentino da Costa, 581, Apt2 303, 58038-580 Joao Pessoa, PB, Brasil.