STAT3

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STAT3

A gene on chromosome 17q21.31 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. The STAT3 protein product mediates expression of various genes in response to cell stimuli, and thus plays a key role in cell growth and apoptosis. GTPase Rac1 binds and upregulates STAT3; PIAS3 inhibits it.
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References in periodicals archive ?
But special emphasis was also laid on the 'dominance of the spetsy', meaning the pre-revolutionary specialists, and on the top brass of the old army (APRF, 3/46/330, 79-82, 85-93).
Alternative Policy Reaction Function (APRF): Following the practices of other studies [e.g., Havrilesky (1967) and Froyen (1974)], our standard monetary policy reaction function included, on the RHS, the contemporaneous values for the target variables.
92 zasedaniia Politbiuro TsK ot 16 marta 1932 g.," APRF f.
These materials were transferred from the Archive of the President of the Russian Federation (APRF) to the Russian State Archive of Sociopolitical History (RGASPI) in March 1995.
This is not a trivial point, for Pikhoia was the director of the Russian Archives Agency from 1990 to 1996 and in this capacity had a unique opportunity to consult classified documents from the Presidential Archives (APRF), which are closed to foreigners and to most Russian historians.