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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Academy of Pharmaceutical Physicians and Investigators.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
In response to the specific points raised, we cannot identify overwhelming experimental data in the references quoted that APPI is preferable to APCI.
Therefore, focus has shifted to the application of APCI and APPI sources for their ionisation.
APPI warned that an increase in the benchmark interest rate on Bank Indonesia promissory notes (SBI) and falling value of the rupiah will not only put a brake on the expansion of multi-finance industry but also endanger its existence.
A statistically generated sampling scheme used a cross-section of the APPI Salmonella-positive samples, on the assumption of 175 Salmonella-positive samples per month.
Through the program, APPI's team of engineers, industry analysts, and regulatory experts acts as each customer's independent consultant to look for overcharges and billing errors and then to secure the related refunds.
(APPI), New York, NY, has signed a marketing and distribution agreement with Tele-V, Inc., Hoofddorp, The Netherlands.
A new ion source from Thermo that offers both atomic pressure photoionization (APPI) and atmospheric pressure chemical ionization (APCI) combines the advantages of both electrospray and photoionization.
Moore is president of Affiliated Power Purchasers International LLC (APPI), the Salisbury, Md., consultant retained by the Newspaper Association of America (NAA) to help members get the best electricity and natural-gas rates by shopping for prices and negotiating based on participating members' aggregated demand.
K., 'Surface Reactivity of Si Nanowires', Appi. Phys., 89:6396-6399, 2001.
NSC works with APPI, an energy consulting/buying cooperative, to lower utility costs by pooling gas and electric commercial and residential accounts in deregulated states, and by providing bill auditing within states stili preparing for deregulation.