apolipoprotein E

(redirected from APOE gene)

ap·o·lip·o·pro·tein E

an apolipoprotein found in several plasma lipoprotein particles including chylomicrons, VLDL, and HDL. Three major isoforms are encoded by three common alleles at the Apo E locus: E2, E2, and E4. The E2 allele is associated with lower total plasma cholesterol and LDL cholesterol than is E3, whereas E4 is associated with higher LDL and total cholesterol than E3.

apolipoprotein E

a protein component of lipoprotein complexes found in very-low-density lipoprotein (VLDL), high-density lipoprotein, chylomicrons, and chylomicron remnants. It facilitates hepatic uptake of chylomicron and VLDL remnants and is elevated in patients with type III hyperlipoproteinemia. One form of apolipoprotein E has been linked to Alzheimer's disease.


A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.

Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.

apolipoprotein E

A 34-kD cholesterol-binding glycoprotein, which comprises 15% of VLDL; apoE maps to chromosome 19, is secreted by macrophages that mediate the uptake of lipoproteins–VLDL, HDL, LDL and cholesterol esters into cells via distinct binding domains for each receptor; apo-E has a central role in the metabolism of TG-rich lipoproteins, and mediates the uptake of chylomicrons and VLDL by the liver
References in periodicals archive ?
10] Some cross-sectional studies evaluated the effect of the APOE genotype on dementia [14],[61],[66],[73],[83],[84],[85],[86] and concluded that APOE gene expression might be correlated with the development of cognitive decline of PD.
The APOE gene influences an individual's risk for the more common late-onset type of Alzheimer's.
The ApoE gene is a confirmed genetic risk factor that influences both the risk and age at onset of Alzheimer's disease and Parkinson's disease (10).
Poor POEM performers were found more likely to have the variant of the APOE gene, which is linked with increased risk of AD.
Its seemingly complex isoform polymorphism involves 3 isoforms that differ by single amino acid interchanges at residues 112 and 158, resulting from single base changes in the APOE gene.
APOE gene expresses in three common isoforms E2, E3 and E4 encoded by e2, e3 and e4 co-dominant alleles respectively.
A reduction of ApoE gene type that contains two cysteines decreases detoxification capabilities and the removal of mercury and other thiol-reactive toxicants.
Based on the results shown in table 3, the plasma adiponectin levels of the mice were significantly affected by the ApoE gene knockout, but the effects of the aerobic exercise were negligible in both the Apo[E.
Axmacher and colleagues looked for signs of trouble in brains of young adults who have a copy of the e4 version of the APOE gene, avariant linked to increased risk for Alzheimer's.
Genotyping, particularly of ApoE gene alleles is also useful in the evaluation of cases and planning management.
Whereas the ApoE secretory pathway includes the different APOE gene variants, the methylation pathway is represented by MTHFR and CBS gene polymorphisms and the status of COMT V158M affects the neurotransmitter balance.