APOE


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APOE

A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.

Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.

APOE

ε4 Molecular neurology The type 4 allele of the apolipoprotein E gene locus located on chromosome 19, which may↑ the risk of late-onset Alzheimer's disease, and has been associated with ↓ cerebral parietal metabolism; possession of an APOE ε4 allele is a strong predictor for cognitive decline. See Alzheimer's disease.

apolipoprotein

(ap?o-li?po-pro'te(-i)n) [ apo- + lipoprotein],

Apo

Any of the proteins imbedded in the outer shell of lipoproteins. The apolipoproteins are designated ApoAI, ApoAII, ApoAIV; ApoB48 and B100; ApoCI, ApoCII, ApoCIII; and ApoE. Except for ApoAII and ApoAIV, they metabolize and transport lipoproteins. The functions of ApoAII and ApoAIV are not fully understood. All are synthesized in the liver.

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.

apolipoprotein J

Clusterin. See: lipoprotein

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.
See also: apolipoprotein
References in periodicals archive ?
Traffic-related air pollution, APOE [epsilon]4 status, and neurodevelopmental outcomes among school children enrolled in the BREATHE project (Catalonia, Spain).
As the [epsilon]4 allelic variant of the apolipoprotein E gene (APOE) is the most significantly AD-associated genetic factor confirmed in a number of populations [24-29], we have also analyzed its presence in our study groups and included its carriage status as a possible confounding variable in ITGA4 association analysis.
Apolipoprotein E (APOE), with regard to longevity, can be said to be the most extensively studied gene [1].
Some genes, such as apolipoprotein E (ApoE) and microtubule-associated protein tau (MAPT), are of particular interest because of their known association with dementia in other neurodegenerative diseases, such as Alzheimer's disease (AD) and atypical parkinsonian syndromes, including progressive supranuclear palsy and corticobasal degeneration (Morley et al., 2012) [5].
As an observation, most tissues from apoE KO mice under a HFD had higher [sup.111]In-DANBIRT retention.
With technological developments, researchers have begun to explore the risk factors for PDD at a genetic level, and the APOE, MAPT, SNCA, GBA, LRRK2, and COMT genes have been found to play a role in the onset and development of PDD [10].
The results indicated that LXR[alpha] down regulated PPAR[alpha], PPARI3, ABCA1, LPL, ApoE genes after 48 h post-pLenti-03 viruses' infection.
Apolipoprotein E (APOE) is one of the genes (19q13.2) that is implicated in causation of gastric cancer (De Feo et al.
In comparison, targeting the major genetic risk factor--the ApoE gene--would prevent less than one in 10 dementia cases (7 percent).
"What we found was that when ApoE is there, it amplifies the toxic function of tau, which means that if we can reduce ApoE levels we may be able to stop the disease process."
These included: APOE (Assaypro, US), Leptin (Assaypro, US), CFH (Cusabio, China) and HTRA1 (EIAab, China).