APOE
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APOE
A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.
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APOE
ε4 Molecular neurology The type 4 allele of the apolipoprotein E gene locus located on chromosome 19, which may↑ the risk of late-onset Alzheimer's disease, and has been associated with ↓ cerebral parietal metabolism; possession of an APOE ε4 allele is a strong predictor for cognitive decline. See Alzheimer's disease.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
apolipoprotein
(ap?o-li?po-pro'te(-i)n) [ apo- + lipoprotein],Apo
Any of the proteins imbedded in the outer shell of lipoproteins. The apolipoproteins are designated ApoAI, ApoAII, ApoAIV; ApoB48 and B100; ApoCI, ApoCII, ApoCIII; and ApoE. Except for ApoAII and ApoAIV, they metabolize and transport lipoproteins. The functions of ApoAII and ApoAIV are not fully understood. All are synthesized in the liver.
apolipoprotein E
Abbreviation: ApoEA protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.
apolipoprotein J
Clusterin. See: lipoproteinapolipoprotein E
Abbreviation: ApoEA protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.
See also: apolipoprotein
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