APOE


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APOE

A gene on chromosome 19q13.2 that encodes apolipoprotein E, the main apoprotein of chylomicrons, which binds to a specific receptor on liver cells and peripheral cells. ApoE mediates binding, internalisation and catabolism of lipoprotein particles and serves as a ligand for the LDL (apo B/E) receptor.

Molecular pathology
APOE mutations cause hyperlipoproteinaemia type III (familial dysbetalipoproteinaemia), which is characterised by increased plasma cholesterol and triglycerides due to impaired chylomicron and VLDL remnant clearance.

APOE

ε4 Molecular neurology The type 4 allele of the apolipoprotein E gene locus located on chromosome 19, which may↑ the risk of late-onset Alzheimer's disease, and has been associated with ↓ cerebral parietal metabolism; possession of an APOE ε4 allele is a strong predictor for cognitive decline. See Alzheimer's disease.

apolipoprotein

(ap?o-li?po-pro'te(-i)n) [ apo- + lipoprotein],

Apo

Any of the proteins imbedded in the outer shell of lipoproteins. The apolipoproteins are designated ApoAI, ApoAII, ApoAIV; ApoB48 and B100; ApoCI, ApoCII, ApoCIII; and ApoE. Except for ApoAII and ApoAIV, they metabolize and transport lipoproteins. The functions of ApoAII and ApoAIV are not fully understood. All are synthesized in the liver.

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.

apolipoprotein J

Clusterin. See: lipoprotein

apolipoprotein E

Abbreviation: ApoE
A protein that regulates lipid concentrations in plasma and may repair neuronal damage in the central nervous system. ApoE4 allele is associated with familial late-onset Alzheimer disease, possibly because it protects neurons less effectively than other ApoE alleles.
See also: apolipoprotein
References in periodicals archive ?
The present study provides evidence that elevated serum APOE and HTRA1 levels and reduced leptin and CFH levels are related to AMD.
Six isoforms of APOE gene are encoded by three e2, e3 and e4 co-dominant alleles.
Genotipificacion de polimorfismos en APOE: el gen APOE se tipifico usando PCR como describieron Hixson et al (40).
When cargo arrives at the APOE, GATES requires that it be checked into the system in preparation for its onward movement to the warfighter.
To assess the role of interaction of APOE [epsilon]4 allele and sex with this polymorphism, the stratified analysis was performed regarding the existing APOE [epsilon]4 PCR results with these samples.
Herein we review the literature to date on sleep apnea in TBI and outline the evidence to suggest that these factors in combination with the presence of the APOE [epsilon]4 may contribute significantly to cognitive dysfunction and the development of dementia in these patients.
These mice have the human APOE locus construct in the correct genetic locus.
In accordance with these regulations, HAZMAT shipments entered into the DTS require a trained and certified shipper, proper packaging, and proper documentation upon arrival at the APOE.
The APOE gene comes in several different forms, or alleles, but three occur most frequently: APOE [epsilon]2, APOE [epsilon]3, and APOE [epsilon]4.
The new method is based on the association between Alzheimer's disease and the APOE e4 gene, which is present in approximately one of every five people.