APOC3

APOC3

A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.
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The paper, titled "Antisense Inhibition of APOC3 in Patients with Hypertriglyceridemia" (Gaudet et al, N Engl J Med 2015: published online July 29), reported data from the Phase 2 study of volanesorsen, a double-blind, randomized, placebo-controlled 13-week study designed to assess the safety and activity of volanesorsen in patients as a monotherapy and as an add-on to fibrates.
Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine
One in 20 Amish people has a mutation that destroys a gene, APOC3, involved in triglyceride metabolism, as compared with one in 150 Americans generally.
In gene, a path to fight heart attacks
In support, a genome-wide association study in the inbred Old Order Amish identified heterozygosity for a null mutation (R19X) in APOC3 (apolipoprotein C-III) resulting in lower triglycerides and a decrease in coronary artery calcification as a marker for subclinical atherosclerosis (8), suggesting that lifelong deficiency of apolipoprotein C-III promoting triglyceride hydrolysis may have a cardioprotective effect.
Low nonfasting triglycerides and reduced all-cause mortality: a mendelian randomization study
Finally, in 190 affected sibling pairs from a cohort of Asian Indian families with a strong history of premature coronary artery disease, the Sac-1 single nucleotide polymorphism in the APOC3 gene and hypertension were contributory factors to this atherogenic trait; circulating apoA-I in participants (distinct from HDL-cholesterol) was highly significantly and positively correlated with serum apoB and triglycerides (28).
Increased apolipoprotein A-I levels mediate the development of prehypertension among Turks/Artmis apolipoprotein A-I duzeyleri prehipertansiyon gelismesine Turk yetiskinlerinde aracilik etmektedir
Modeling the influence of APOC3, APOE, and TNFpolymorphisms on the risk of antiretroviral therapy-associated lipid disorders.
A pharmacogenomical perspective in HIV/AIDS therapies
The gene, known as APOC3, produces a protein, apoC-III, that normally inhibits the breakdown of triglycerides.
Fat protection gene; In association with the NHS
The gene, known as APOC3, produces a protein that normally inhibits the breakdown of triglycerides.
Gene can protect from heart disease
Ordovas and coworkers have also found mutations on APOB and APOC3.
Attacking Heart Disease at Its Genetic Base
The researchers' findings, together with other recent genetic discoveries - specifically, the identification of protective mutations in the APOC3 gene that lower triglyceride levels and the risk of heart attack - refocus attention on abnormal triglyceride metabolism as an important risk factor for heart attack at any age.
Rare Gene Mutations Raise Risk Of Early Heart Attack
13 (G) APOC3, APOA1 13q34 rs4773144 COL4A1, COL4A2 0.
9p21 and the genetic revolution for coronary artery disease
Pollin said that those with this mutation of the APOC3 gene have higher levels of HDL-cholesterol, the so-called "good" cholesterol, and lower levels of LDL-cholesterol, the "bad" cholesterol.
Gene mutation that appears to prevent heart disease identified
CMHC's unparalleled faculty will present novel research and treatment approaches ranging from the role of inflammation in CVD to significant genetic discoveries, including PCSK9 inhibition and APOC3 polymorphisms, to the bionic pancreas and the impact of gut microbiota on obesity.
Cardiometabolic Health Congress: Game Changing Science Meets Clinical Practice in Boston

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