APOC1

APOC1

A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.
Mentioned in ?
References in periodicals archive ?
Furthermore, chromosome 19q13.32, a gene rich region consisting of TOMM40, ApoE, and APOC1 genes, is implicated in several phenotypes including AD.
Over-expression of human apolipoprotein C1 (APOC1) with hyperlipidemia in transgenic mice causes hair growth disorders correlated with the level of expression of human APOC1 gene in the skin [11, 73].
North et al., "A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains," PLoS Genetics, vol.
Proteomics studies on AH showed that APOC1 (one of apolipoproteins, proteins involved in lipid transport and metabolism) was overexpressed in patients with Coats' disease [36], while another apolipoprotein (APOD) was found decreased in AH of patients with pseudoexfoliation syndrome [14].
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
In addition, we examined several genes [e.g., ESRP1/2 (epithelial splicing regulatory protein 1 and 2), [9] OVOL1/2 (ovo-like zinc finger 1 and 2), HBA1 (hemoglobin, [alpha]1), APOC1 (apolipoprotein C-1)] that are known to be highly specific to epithelial cells or leukocytes, the major types of cells in saliva.
[9] Human genes: ESRP1I2, epithelial splicing regulatory protein 1 and 2; OVOL1I2, ovo-like zinc finger 1 and 2; HBA1, hemoglobin, [alpha]1; APOC1, apolipoprotein C-1; EIF3E; eukaryotic translation initiation factor 3, subunit E; DDOST; dolichyl-diphosphooligosaccharide-protein glycosyl transferase subunit (non-catalytic); DOPEY2, dopey family member 2; UBAP2, ubiquitin associated protein 2; GSE1, Gse1 coiled-coil protein; ASXL1, additional sex combs like transcriptional regulator 1; UGP2, UDP-glucose pyrophosphorylase 2; WDFY1, WD repeat and FYVE domain containing 1.
In addition to the ABC transporters, several apolipoproteins involved in reverse cholesterol transport, including ApoE, ApoC1, ApoC2, and ApoC4, are also transcriptional targets for LXRs [86, 87].
Overexpression of human apolipoprotein C1 (APOC1) with hyperlipidemia in transgenic mice results in abnormal hair growth correlated with the expression of the human APOC1 gene in the skin [18, 49].
Mass spectrometryanalysis of tissue extracts identified only 5 of the candidate biomarkers in the samples analyzed: apolipoprotein C1 (APOC1, gel 8), asporin (ASPN, gel 5), complement C4A (gel 8), 6-phosphogluconolactonase (PGLS, gel 7), and ribosomal protein L22-like 1 (RPL22L1, gel 8).
Oxidation markers under consideration were sulfoxidized apoAI and apoC1. Truncation markers were found as N-terminal dipeptide truncations on RANTES and apoC1.
In contrast, peptides from the following apolipoproteins were identified in the lipoprotein particle fractions: ApoA1, ApoA2, ApoA4, ApoB, ApoC1, ApoC2, ApoC3, ApoC4, ApoD, ApoE, ApoF, ApoL, ApoM, and lipoprotein(a).