APOC1

APOC1

A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.
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APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
ESRP1/2 (epithelial splicing regulatory protein 1 and 2), [9] OVOL1/2 (ovo-like zinc finger 1 and 2), HBA1 (hemoglobin, [alpha]1), APOC1 (apolipoprotein C-1)] that are known to be highly specific to epithelial cells or leukocytes, the major types of cells in saliva.
9] Human genes: ESRP1I2, epithelial splicing regulatory protein 1 and 2; OVOL1I2, ovo-like zinc finger 1 and 2; HBA1, hemoglobin, [alpha]1; APOC1, apolipoprotein C-1; EIF3E; eukaryotic translation initiation factor 3, subunit E; DDOST; dolichyl-diphosphooligosaccharide-protein glycosyl transferase subunit (non-catalytic); DOPEY2, dopey family member 2; UBAP2, ubiquitin associated protein 2; GSE1, Gse1 coiled-coil protein; ASXL1, additional sex combs like transcriptional regulator 1; UGP2, UDP-glucose pyrophosphorylase 2; WDFY1, WD repeat and FYVE domain containing 1.
In a sub-set of the cohort selected for neutral risk at the APOE locus, they detected a significant association in SNPs located within TOMM40 and APOC1, two genes that flank APOE.
Statistical significance was confirmed with a Satterthwaite t-test for APOC1, CXCL11, and CXCL9.
We identified 7 novel biomarkers as statistically significant in discriminating protein concentrations in blood from men with advanced prostate cancer compared to controls: APOC1, ASPN, COMP, CXCL11, CXCL9, F5, and PCSK6.