APOA5

APOA5

A gene on chromosome 11q23 that encodes apolipoprotein A-V, a minor apolipoprotein mainly associated with high-density lipoprotein (HDL), less so with VLDL and chylomicrons. It is an important determinant of plasma triglyceride (TG) levels, both stimulating TG hydrolysis by apo-CII lipoprotein lipase and inhibiting VLDL-TG production.
References in periodicals archive ?
(8) Researchers Corella and Ordovas, who explored the correlation between variants of the APOA5 gene, lipid metabolism and body-mass index (BMI), found a scientific explanation.
The association between APOA5 gene polymorphisms and plasma lipids in the Turkish Cypriot population: A Possible biomarker for preventing cardiovascular diseases.
Thyroid hormone regulates the hypotriglyceridemic gene APOA5. J Biol Chem 2005; 280(30):27533-43.
A proximal part of Chr 9 is known to have many genes relevant to lipid metabolism, including Apoa1, Apoc3, Apoa4, Apoa5, and Lipc, and multiple QTL including Cq4, Cq5, and Hdlq17 [17] have been reported.
The changes were associated with increased APOA5 and acetyl-CoA oxidase genes expression in the mice that were fed a diet supplemented with 9 mg/mouse/day of OxLA.
In this regard, the aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism (namely, TCF7L2, PPARG2, PPARGC1A, carbohydrate metabolism; FTO, MC4R, APOA5, LDLR, GCKR, fat metabolism; MTHFR, folate metabolism).
The remaining 2 discrepancies were found in noncoding regions of the genes apolipoprotein A-V (APOA5) [4] and platelet-derived growth factor receptor beta (PDGFRB), and had MPG quality scores of 4 and 10, respectively (10).
Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia aiter treatment with highly active antiretroviral therapy containing protease inhibitors in HIV-infected individuals in Taiwan.
Additive effects of APOE, APOA5 and LPL, variants combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study.
The study, which was published in the Journal of Lipid Research, sought to appraise the relationship of carriers of variants of the APOA5 gene to atherosclerosis, or hardening of the arteries.