APOA4

APOA4

A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
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In heifers, expression analysis of 40 candidate genes chosen by RNA-Seq resulted in dynamic, significantly regulated genes with extreme fold regulation values, ranging from 5-fold downregulation (APOA4) up to 82-fold up-regulation (SerpinI2).
Por otro lado, las cantidades relativas de apoA4 y de la isoforma mayor de apoAI, asi como apoE, se encontraron en menor proporcion en las LDL de los sujetos obesos; sin embargo, esta diferencia solo se observo en sujetos del genero masculino.
A proximal part of Chr 9 is known to have many genes relevant to lipid metabolism, including Apoa1, Apoc3, Apoa4, Apoa5, and Lipc, and multiple QTL including Cq4, Cq5, and Hdlq17 [17] have been reported.
Genes and gene products associated with blood microparticle (GO:0072562) can be found by the GO tool, in which APOA4 (Apolipoprotein A4), kng1 (Kininogen 1), and other genes have been illustrated to be associated with cholangiocarcinoma [39-41].
For the SID-MRM analysis, we first synthesized stable-isotope standard (SIS) peptides (>95% purity) for 15 proteins (APLP2, APOA4, APOH, B3GNT1, C4B, C5, C7, CD14, CLU, FN1, GSN, ITIH2, KRT1, SERPINF1, and VTN).
As compared to healthy controls, the whole RTT group showed significant increase in 10 protein spots [i.e., complement factor B (CFAB), fibrinogen alpha chain (FIBA), serum albumin (ALBU, spots number 3, number 7 C terminal fragment and number 14 N terminal fragment) alpha-1-antitrypsin (A1AT, spots number 4 and number 5), haptoglobin (HPT, spots number 9 and number 15), and transthyretin (TTHY spot number 11)] and decrease in 6 protein spots [i.e., vitamin D-binding protein (VTDB), apolipoprotein A4 (APOA4), clusterin (cLuS), apolipoprotein A1 (APOA1), retinol-binding protein 4 (RET4), and transthyretin (TTHY spot number 16)] (Table 1 and Figures 1(a), 1(b), and 2(a)).
2004)--were affected by Western diet in B6 and B6.D2 mice: ApoA4 ([up arrow]15.9-fold and [up arrow]10.2-fold), which is involved in innate immunity and fat localization (Shen et al.
Las apoproteinas tienen caracteristicas comunes, incluido el hecho de que las tres cuartas partes de las plasmaticas circulantes se producen en el higado, pero la mayoria de las apoA1 y apoA4 se producen en el intestino.
On the other hand, notes Ordovas, "people with a specific mutation of the APOA4 gene have less than half as much improvement in blood lipids from the cholesterol-lowering diet as those with no mutation." But in a study by other researchers, he adds, people with a different APOA4 mutation consumed a high-cholesterol diet without raising their blood cholesterol.
The eight differentially expressed proteins included third party data (TPA): vitamin D-binding protein precursor (GC), complement C4 precursor (C4), paraoxonase 1 (PONI), A2M, endopin 1 (EN1), TPA: apolipoprotein A-IV precursor (APOA4), alpha-1-antitrypsin, and haptoglobin (HP).
APOA2 is a member of the apolipoprotein multigene superfamily, which includes genes encoding soluble apolipoproteins (e.g., APOA1 and APOA4) that share genomic structure and several functions.
The 1.6-fold increase in Cyp7b1 (Table 1), and the downregulation of fatty acid-binding protein-2 (Fabp2) and apolipoprotein AIV (Apoa4) (Table 2), provide further evidence of the possible involvement of CYP1A2 in fatty acid and cholesterol pathways.