APOA1

APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
References in periodicals archive ?
Differentially expressed genes enriched in KEGG pathways Number Metabolic pathway Number of DEGs 1 PPAR signaling 12 pathway 2 Insulin signaling 14 pathway 3 Fructose and mannose 4 metabolism 4 GnRH signaling 5 pathway 5 TGF-beta signaling 4 pathway Number Genes Pathway p-value ID 1 CYP8B1, APOA1, AQP7, SLC27A6, Ko03320 0.
4] Human genes: ABCA1, ATP binding cassette subfamily A member 1; LCAT, lecithincholesterol acyltransferase; APOA1, apolipoprotein A1.
Para la determinacion de APOA1 y APOB, se utilizo el equipo automatizado (A25 Immunochemistry Biosystems') mediante turbimetria con anticuerpos anti-apolipoproteinas respectivamente.
At odds with this, rare allelic variants of three candidate genes (ABCA1, APOA1, LCAT) that influence HDL levels, were jointly found to make a substantial contribution to the population distribution of HDL levels (25,26).
Myeloperoxidase, APOA1, OxLDL, HDL, TG, LDL, and cholesterol were assessed The level of cholesterol, TG, HDL, LDL, myeloperoxidase, APO A1, and OxLDL was 5.
So the Spanish researchers, under Ordovas' guidance, looked for a gene-gene interaction between these APOA1 and APOA4 mutations.
Plasma ApoA1 level was reported to be genetically influenced by APOA1 gene (rs670) with a single nucleotide polymorphism at position - 75 bp in the gene promoter, and the allele of rs670 was reported to be related to higher plasma ApoA1 and HDL levels.
In the second predicted pathway (Figure 1B), ADD3, along with MSRA and CD47, may also interact independently with APOA1 (apolipo-protein A-1) and CAV1 (caveolin 1, caveolae protein, 22kDa) to regulate biological quality, homeostasis, cellular components of movement, positive regulation of biological process, and response to stimuli (p= 2.
3 VALORES DE APOA1 (G/L) SEGUN LA PRESENCIA DE MALARIA Y EL RIESGO DE DESNUTRICION EN NINOS (1) Riesgo de Con malaria (n = 183) Sin malaria (n = 79) desnutricion X (2) DE X DE Ninguno (3) 0.
2] Human genes: PCSK9, proprotein convertase subtilisin/kexin type 9; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; APOA1, apolipoprotein A-I; LCAT, lecithin-cholesterol acyltransferase.
To create synthetic HDL the researchers started with a gold nanoparticle as the core, which was then layered on a lipid that attaches to the gold surface, followed by another lipid and last a protein, called APOA1.
13 (G) APOC3, APOA1 13q34 rs4773144 COL4A1, COL4A2 0.