Differentially expressed genes enriched in KEGG pathways Number Metabolic pathway Number of DEGs 1 PPAR signaling 12 pathway 2 Insulin signaling 14 pathway 3 Fructose and mannose 4 metabolism 4 GnRH signaling 5 pathway 5 TGF-beta signaling 4 pathway Number Genes Pathway p-value ID 1 CYP8B1, APOA1
, AQP7, SLC27A6, Ko03320 0.
4] Human genes: ABCA1, ATP binding cassette subfamily A member 1; LCAT, lecithincholesterol acyltransferase; APOA1
, apolipoprotein A1.
Para la determinacion de APOA1
y APOB, se utilizo el equipo automatizado (A25 Immunochemistry Biosystems') mediante turbimetria con anticuerpos anti-apolipoproteinas respectivamente.
At odds with this, rare allelic variants of three candidate genes (ABCA1, APOA1
, LCAT) that influence HDL levels, were jointly found to make a substantial contribution to the population distribution of HDL levels (25,26).
, OxLDL, HDL, TG, LDL, and cholesterol were assessed The level of cholesterol, TG, HDL, LDL, myeloperoxidase, APO A1, and OxLDL was 5.
So the Spanish researchers, under Ordovas' guidance, looked for a gene-gene interaction between these APOA1
and APOA4 mutations.
Plasma ApoA1 level was reported to be genetically influenced by APOA1
gene (rs670) with a single nucleotide polymorphism at position - 75 bp in the gene promoter, and the allele of rs670 was reported to be related to higher plasma ApoA1 and HDL levels.
In the second predicted pathway (Figure 1B), ADD3, along with MSRA and CD47, may also interact independently with APOA1
(apolipo-protein A-1) and CAV1 (caveolin 1, caveolae protein, 22kDa) to regulate biological quality, homeostasis, cellular components of movement, positive regulation of biological process, and response to stimuli (p= 2.
3 VALORES DE APOA1
(G/L) SEGUN LA PRESENCIA DE MALARIA Y EL RIESGO DE DESNUTRICION EN NINOS (1) Riesgo de Con malaria (n = 183) Sin malaria (n = 79) desnutricion X (2) DE X DE Ninguno (3) 0.
2] Human genes: PCSK9, proprotein convertase subtilisin/kexin type 9; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; APOA1
, apolipoprotein A-I; LCAT, lecithin-cholesterol acyltransferase.
To create synthetic HDL the researchers started with a gold nanoparticle as the core, which was then layered on a lipid that attaches to the gold surface, followed by another lipid and last a protein, called APOA1
13 (G) APOC3, APOA1
13q34 rs4773144 COL4A1, COL4A2 0.