APOA1

APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
References in periodicals archive ?
In the second predicted pathway (Figure 1B), ADD3, along with MSRA and CD47, may also interact independently with APOA1 (apolipo-protein A-1) and CAV1 (caveolin 1, caveolae protein, 22kDa) to regulate biological quality, homeostasis, cellular components of movement, positive regulation of biological process, and response to stimuli (p= 2.
At odds with this, rare allelic variants of three candidate genes (ABCA1, APOA1, LCAT) that influence HDL levels, were jointly found to make a substantial contribution to the population distribution of HDL levels (25,26).
So the Spanish researchers, under Ordovas' guidance, looked for a gene-gene interaction between these APOA1 and APOA4 mutations.
The APOE, APOA1, and APOA4 genes are blueprints for some of the apolipoproteins, or apos, for short.
2] Human genes: PCSK9, proprotein convertase subtilisin/kexin type 9; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; APOA1, apolipoprotein A-I; LCAT, lecithin-cholesterol acyltransferase.
13 (G) APOC3, APOA1 13q34 rs4773144 COL4A1, COL4A2 0.
To create synthetic HDL the researchers started with a gold nanoparticle as the core, which was then layered on a lipid that attaches to the gold surface, followed by another lipid and last a protein, called APOA1.
APOA1 is the main protein component of naturally occurring HDL.
We believe CURNA's unique technology may be important for treating diseases in which increased levels of specific proteins are important, such as APOA1 to increase HDL levels to prevent heart disease, and genetic disorders in which higher levels of specific enzymes or other proteins may be beneficial or curative.