adiponectin

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ad·i·po·nec·tin

(ad'i-pō-nek'tin),
Protein hormone produced and secreted by adipocytes into the systemic blood circulation; causes sensitivity of peripheral tissues to insulin.
[adipo- + L. necto, to fasten, + -in]

adiponectin

(ăd′ə-pə-nĕk′tĭn)
n.
A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

Adiponectin

A circulating protein encoded by ADIPOQ on chromosome 3q27, which is secreted exclusively by mature adipocytes. It is a key adipokine in the control of fat metabolism and insulin sensitivity, and has direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilisation and fatty acid hydrolysis. It antagonises TNF-alpha by down-regulating its expression in the liver, macrophages and elsewhere, and by counteracting its direct effects. It inhibits endothelial NF-kappa-B signalling by a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on complex size—low, medium, or high molecular weight.

ad·i·po·nec·tin

(ad'i-pō-nek'tin)
Protective adipokine that reduces lipid accumulation and endothelial adhesion resulting from vascular injury; increases skeletal muscle oxidation of free fatty acids; reduces hepatic glucose output; increases peripheral insulin sensitivity.
[adipo- + L. necto, to fasten, + -in]

adiponectin

A cytokine derived from adipose tissue that has antidiabetic and antiatherosclerotic properties.
References in periodicals archive ?
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
5.7-5.9 - (6) Delomys dorsalis 5.1-5.6 14.9-15.9 (4) (4) Nectomys squamipes 7.1 22.7 Oligoryzomys nigripes 3.5-3.7 13.2-13.9 (5) (5) Oryzomys angouya 5.4 19.3 Oryzomys russatus 5.7 15.7 Oxymycterus misionalis 6.2-6.4 17.7-18.2 (2) (2) APM1 APZ Akodon sp.
Matsubara, "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adiposemost abundant gene transcript 1)," Biochemical and Biophysical Research Communications, vol.
Adiponectin (also called ARCP30, AdipoQ, apM1, and GBP28) is a 247-amino acid peptide hormone discovered in 1995 (3).
Adiponectin was discovered in the 1990s by four independent groups, and it was originally named Acrp30, AdipoQ, apM1, and GBP28.
Adiponectin is also known as Acpr30 (adipocyte complement-related protein 30kDa), apM1 (adipose most abundant gene transcript-1), or GBP 28 (gelatin-binding protein) [13].
Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians.
Dina et al., "Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians," Human Molecular Genetics, vol.
Adiponectin, also known as adipocyte complement-related protein of 30 kDa (ACRP30), adipoQ, adipose most abundant gene transcript 1 (apM1), and gelatin-binding protein of 28 kDa (GBP28), is an adipocyte-specific, secreted protein with roles in glucose and lipid homeostasis.
One of them, adiponectin, also known as Acrp30, AdipoQ, GBP28, and apM1, was discovered by four independent research teams in 1995/1996, [2-5] as the most abundant product of the adipose tissue [6].
Adiponectin (also named apM1, Arcp-30, AdipoQ, or GBP-28), an abundant protein produced by adipose tissue, is regarded as one of the adipokines, which include leptin, resistin, interleukin-6, tumor necrosis factor-a, and plasminogen activator inhibitor-1, and other constituents necessary for endocrinologically active adipose tissue (1-4).