BIRC5

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BIRC5

A gene on chromosome 17q25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. Gene expression is high during foetal development and in most tumours, yet low in adult tissues.

Function
BRIC5 is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilisation and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BRIC5 may play a role in neoplasia, counteract default induction of apoptosis in G2/M phase and inhibit caspase-3 and caspase-7.
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Starting June 1, benchmark API2 coal futures in Rotterdam have rallied 20 percent to around $60 a ton, the highest in a year, while Asia benchmark API4 futures have climbed 15.
It builds on the company's global suite of coal futures and options products, including the benchmark Central Appalachian, Powder River Basin and CSX Coal Futures in the US, and API2 cif ARA, API4 fob Richards Bay, API5 fob Newcastle, API8 CFR South China, Indonesian Coal and Australian Coking Coal, which serve growing markets in Asia and Europe.
Esta proporciona un API4 que permite la creacion de clientes web para el acceso y la manipulacion de la informacion geografica.