APEX2

APEX2

A gene on chromosome Xp11.21 that encodes a weak apurinic/apyrimidinic (AP endoDNAase), which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcription factors. APEX2 has robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA, and preferentially removes mismatched nucleotides; it also has robust 3'-phosphodiesterase-induced removal of 3'-damaged termini formed in DNA by oxidative agents. It is required for somatic hypermutation (SHM) and DNA cleavage step of class-switch recombination of immunoglobulin genes, as well as for proper cell cycle progression during proliferation of peripheral lymphocytes.
References in periodicals archive ?
The Casella Dust Detective encompasses the Microdust Pro real time dust monitor, and the Apex2 air-sampling pump.
APEX2 [19] was used for data collection and SAINT [20] for cell refinement and data reduction.
We used S4800 scanning electron microscopy (Hitachi, Tokyo, Japan) and an EDAX Genesis APEX2 system (Ametek, Paoli, PA, USA).
A data collection strategy consisting of [phi] and [omega] scans was devised using COSMO in APEXII (Bruker, SADABS, APEX2, and SAINT, Bruker AXS Inc., Madison, Wisconsin, USA, 2008).
Company has introduced the next generation of its personal sampling pump: the Apex2 featuring Bluetooth 4.0 wireless connectivity and supporting Airwave app.
An alternative proximity-based labeling system, APEX or APEX2, is not amenable for identification of redox-dependent pathways since it requires cell treatment with hydrogen peroxide to generate biotin-phenoxyl radicals and appears limited to compartmental proteomics [28, 29].
Manchester-based Heyrod is currently on site at five projects in Liverpool including APEX2 (a Liverpool University academic building), Hatton Gardens (a second Liverpool University site providing accommodation), The New Royal Liverpool Hospital, a new docklands exhibition centre and Sefton Street Block 4 (a privately-owned development).
WORLDWIDE COMPUTER PRODUCTS NEWS-May 21, 2014-NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
M2 EQUITYBITES-May 21, 2014-NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
The single crystals obtained were analysed by Bruker SMART APEX2 CCD area detector diffractometer (Figure 1).