APEX1


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APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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Liu et al., "Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy," International Journal of Radiation Oncology Biology Physics, vol.
Uchino et al., "APEX1 Asp148glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese," Asian Pacific Journal of Cancer Prevention, vol.
We examined genetic variants, includingsingle-nucleotide polymorphisms (SNPs) and copy-number variants (CNVs), in three genes involved in the metabolism of DBPs (GSTT1, CYP2E1, and GSTZ1), four additional genes that may play a minor role in the metabolism of DBPs (GSTT2B, GSTM1, CYP1A2, and CYP2D6), and four DNA repair genes that could be relevant when examining results, particularly for the comet assay (APEX1, ERCC2, OGG1, XRCC1).