APEX1

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APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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The human 8-oxoguanine DNA glycosylase 1 (hOGG1) and apurinic/apyrimidinic endonuclease 1 (APE1) genes play an important role in the DNA repair pathway [7] where hOGG1 has primary activity to remove the 8-OHdG from DNA through the BER mechanism whereas APE1 repairs basic AP sites in DNA.
Human APE1 is a major component of the base excision repair in both nDNA and mtDNA [54] in various types of cells, including lung cancer cells [7,55].
Some of the potential dementia fighters now under review in NIH-funded research labs include saracatinib, a cancer drug that blocks Fyn, which is an enzyme associated with Alzheimer; microtubule stabilizing chemicals, which could help researchers get other useful drugs past the barrier that keeps most drugs out of the brain; MW181, a drug that fights brain inflammation; APE1, an enzyme that helps brain cells repair DNA; and Citalopram, an antidepressant already on the market that might keep beta-amyloid plaques from coating neurons.
Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans.
GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study.
000 sitios AP que son reparados por una maquina proteica, el reparosoma, formado por cuatro proteinas que actuan asi: la UDG (Uracil-DNA glicosilasa, que elimina el uracilo), APE1 (AP-endonucleasa humana, que corta la cadena azucar-fosfato y funciona como un factor de reduccion-oxidacion (redox) y mantiene los factores de transcripcion en un estado activo reducido (32), la polimerasa P (que introduce el nucleotido que faltaba) y la ligasa (que sella el corte) (34, 35).
Association of DNA Base-excision Repair XRCC1, OGG1 and APE1 Gene Polymorphisms with Nasopharyngeal Carcinoma Susceptibility in a Chinese Population.
They found that by blocking a cell repair enzyme called APE1 with special molecules, they had developed stopped two repair routes at once.
Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide.
The APE1 protein is a critical molecular "switch" controlling the activity of cancer regulatory proteins, including transcription factors HIF-1-alpha, STAT3, NF-kappa B, and AP-1.
The X-ray repair cross-complementing (XRCC) 1 plays a central role in the DNA BER pathway, as it serves as a scaffolding protein interacting with DNA ligase III, DNA pol[beta], APE1, and PARP1 [59].