is a common risk factor for thrombosis, and between 20% and 60% of thrombophilic patients suffer from some form of APC resistance
All assessments were reported to be within normal physiological limits except for the APC resistance
assay, which was reported low at 0.
Our excellent HemosIL and Chromogenix reagent product line offers a broad spectrum of diagnostic tests, including assays for the detection of APC resistance
and factor V Leiden mutations.
When testing for factor V Leiden, a screening test is done to determine APC resistance
This finding is in agreement with the fact that patients with the FV-Leiden mutation show APC resistance
Sensitivity and specificity of the APC resistance
assay in detection of individuals with factor V Leiden.
(functional test for Factor V Leiden)
The technology provides data in concordance with the existing method of detecting APC resistance
, known as the Activated Partial Thromboplastin Time (APTT) assay.
24) reported that the presence of LA was significantly associated with acquired APC resistance
(APC-R) in patients with SLE.
Approximately 95% of individuals with functional APC resistance
have the FVL mutation, which can be detected by a polymerase chain reaction amplification of a 223-base pair (bp) fragment after MnlI cleavage, (21) but newer assays by invader probe, Third Wave technology, and Light Cycler technology have also been developed (Figure 5).