Activated Protein C ResistanceAn inherited (autosomal dominant) or acquired defect in the anticoagulant response to activated protein C, resulting in an increased risk of thrombosis.
Clinical findings Increased risk of deep vein thrombosis (DVT), venous thrombosis; it is responsible for 20% to 50% of DVT.
Pathogenesis Protein C, a key regulator of coagulation, circulates in an inactivated form and is activated by the binding of thrombin to thrombomodulin receptors on vascular endothelial cells; once activated, protein C lyses coagulation factors Va and VIIIa. Activated protein C resistance is caused by a failure of protein C to cleave Factor Va and/or Factor VIIIa.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
APC resistanceActivated protein C resistance, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
APC resistanceAbbrev. for activated protein C resistance, an abnormal tendency to blood clotting caused by a mutation in the gene for blood clotting factor V. This mutation is known as the FACTOR V LEIDEN MUTATION. APC resistance is the commonest cause of inherited THROMBOPHILIA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005