AP3S2 | definition of AP3S2 by Medical dictionary
AP3S2 A gene on chromosome 15q26.1 that encodes a subunit of the heterotetrameric AP3 complex, an adaptor-related protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes, budding of vesicles and trafficking to lysosomes.
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References in periodicals archive
As shown in Table 1, six of these genes (ZNF256, CPLX2, LOC646820, SLC38A1, PGBD3, and AP3S2
) were associated with alcohol dependence at the p < 0.01 level in both EAs and AAs.
Using a relatively modest sample size (5,561 cases and 14,458 controls in the discovery step) five additional novel T2D loci were discovered : HNF4A, involved in monogenic forms of diabetes and associated with [beta]-cell development ; GRB14 which is associated with obesity and insulin resistance ; and another three loci with less clear functions; AP3S2
, ST6GAL1 and VPS26A .