AP2M1

AP2M1

A gene on chromosome 3q28 that encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. AP2M1 is required for the activity of a vacuolar ATPase, which is responsible for proton pumping needed to acidify endosomes and lysosomes. It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein.
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Several upregulated genes play a role in innate immunity and are expressed in neutrophils (i.e., defensin, alpha 1, DEFA1, Fc fragment of IgA, receptor, and FCAR), dendritic cells (i.e., Dab, mitogen-responsive phosphoprotein, and homolog 2 DAB2), and in macrophages (adaptor-related protein complex 2, mu 1 subunit, and AP2M1).
Through coexpression network construction and analysis of node degree, we found some functional and high connected hubs varied in EC and HIP region, such as CHRM1, MAPK1, TGFBR1, LIFR, ERBB4, ERBIN, ATP5C1, IGF1R, GJA1, TJP1, AP2M1, CDK5, FGF2, TUBB, SLC22A3, DBT, CDK13, NLN, and MIF.
These genes included STXBP1, NAPA, AP2M1, CPLX2, CPLX1, and STX1B, which participate in exocytosis of vesicles loaded with a neurotransmitter, coordinated recovery of SVs by endocytosis, refilling of vesicles, and subsequent release of the refilled vesicles from the presynaptic bouton.
The validated target genes for miR-224 are AP15 (apoptosis inhibitor 5) (21), AP2M1 (adaptor-related protein complex 2, mu 1 subunit) (33), CDC42 [cell division cycle 42 (GTP binding protein, 25 kDa)], CXCR4 [chemokine (C-X-C motif) receptor 4] (30), SMAD4 (SMAD family member 4) (34), SMAD5 (SMAD family member 5) (17), SLMAP (sarcolemma-associated protein) (17), H3.3B [H3 histone, family 3B (H3.3B)] (17), D1O1 (deiodinase, iodothyronine, type I) (16), DMN1 (33), VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase) (35), H1F1A [hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)] (35), KLK10 (kallikrein-related peptidase 10) (31), and KLK1 (kallikrein 1) (36).