AP1G2A gene on chromosome 16q23 that encodes a large subunit of the heterotetrameric, trans-Golgi, clathrin-associated adaptor-related protein complex AP-1, which is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. The vesicles are involved in endocytosis and Golgi processing; AP complexes recruit clathrin to membranes and recognise sorting signals within the cytosolic tails of transmembrane cargo molecules. AP1G2 may function in protein sorting in endosomes or multivesicular bodies.
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