AP-2 transcription factor | definition of AP-2 transcription factor by Medical dictionary
TFAP2A (redirected from AP-2 transcription factor)
TFAP2A A gene on chromosome 6p24 that encodes a member of the AP-2 family of transcription factors, which activate the transcription of genes involved in proper eye, face, body wall, limb and neural tube development. TFAP2A inhibits C/EBP alpha, MCAM/MUC18 and MYC.
TFAP2A mutations cause branchiooculofacial syndrome.
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References in periodicals archive
Gumbs et al., "Expression of AP-2 transcription factors
in human breast cancer correlates with the regulation of multiple growth factor signalling pathways," Cancer Research, vol.
AP-2 transcription factors
are localized predominantly in the nucleus where they bind to target sequences and regulate transcription of target genes (Dawid et al., 2005).