fos

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FOS

A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.

fos

(fas)
A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation

Etiology

The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?
Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes.
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.
Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.