fos

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FOS

A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.

fos

(fas)
A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation

Etiology

The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?
The pleiotropic nature of these organochlorines is revealed in their ability to stimulate expression from a classic ERE promoter element (2,19), activate receptor tyrosine kinases as well as multiple kinase pathways (45,47,48,50,51), inhibit L-type [Ca.sup.2+] channels (99,100) and, as shown here, their capacity to stimulate AP-1 activity through non-ER-mediated mechanisms.
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74:311-317 (2000).
Transcriptional regulation of Fas gene expression by GA-binding protein and AP-1 in T cell antigen receptor.
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells.
The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions.
The oestrogen receptor regulates NFkappaB and AP-1 activity in a cell-specific manner.
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.
The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells.
Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells.
Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells.