APEX1

(redirected from AP endonuclease 1)

APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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Dianov, "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair," Biochemistry, vol.
Madhusudan, "Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer," Cancer Treatment Reviews, vol.
AP endonuclease 1 (Ape1) is the major mammalian abasic endonuclease, accounting for > 95% of the total cellular AP site incision activity (Demple and Harrison 1994).