Among them, CIZ1 (Cip1-interacting zinc finger protein; DYT23), ANO3 (anoctamin 3; DYT24), and GNAL (guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type; DYT25) genes have been discovered for CD [7-9].
Given that ion channels are crucial components of cellular exciting ability and are involved in many neurological diseases, for example, ANO3, whose mutations have detected in sporadic CD, functions as calcium activated chloride channels which modulate neuronal excitability .
Majority of times, this is a primary condition without any underlying pathology and is being attributed to high sphincter tone1, though epidermoid carcinoma of anal canal, tuberculosis, AIDS2 and Crohn's disease can also present with fissure in ano3
. The treatment options available are evolved after a detailed work pertinent to the possible mechanism behind its pathogenesis.