ANGPTL5
ANGPTL5
A gene on chromosome 11q22.1 that encodes angiopoietin-like protein 5, which is expressed mainly in adult heart.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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This protein family includes eight members encoded by eight genes (ANGPTL18) identified in humans and mice, except ANGPTL5, that is a human orthologue [25, 27-29].
ANGPTL5 is mainly expressed in adult human heart [57], whereas ANGPTL6/AGF expression is restricted to liver and plasma [58].
On the other hand, immune inhibitory receptor human leucocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue-paired immunoglobulin-like receptor (PIRB) have been reported to bind several ANGPTL proteins, especially ANGPTL2 and ANGPTL5, in hematopoietic cells (HSC) [22].
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