ANGPTL4

ANGPTL4

A gene on chromosome 19p13.3 that encodes angiopoietin-like protein 4, which is expressed in endothelial cells in response to hypoxia. It is directly involved in regulating glucose homeostasis, lipid metabolism and insulin sensitivity; it may act as a regulator of angiogenesis and modulate tumourigenesis, and may protect endothelial cells by secreted factors. It reduces endothelial cell motility and inhibits sprouting and tube formation.
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It is involved in angiogenesis and encoded by ANGPTL4 gene.
ANGPTL4 has been identified as a multifunctional signal protein.
ANGPTL4 mRNA is expressed in many organs and tissues, highly in WAT, placenta, liver, muscle (Feingold et al.
In view of structure differences between species and the essential role in fat metabolism of ANGPTL4 gene, study on the cDNA sequence and expression of ovine ANGPTL4 gene may help us to understand the genetic mechanism of fat metabolism in different sheep breeds.
Quantitative real-time polymerase chain reaction (QRT-PCR): primers were designed to span an exon-exon boundary based on the coding sequence of ovine ANGPTL4 gene.
Quantitative real-time PCR: Relative ANGPTL4 expression was quantified by using the 2-[delta][delta]Ct method with an ABI Prism 7500 sequence detector (Applied Biosystems) and SYBR Premix Ex TaqTM kit (Takara, Japan), following the manufacturer's instructions.
To characterize the temporal expression features of ANGPTL4 mRNA in the two breeds under study, the relative expressions in each and whole adipose tissue were also analyzed by fitting time-series models and conducted by Minitab 16 (Minitab Inc.
001) were the main effects influencing the ANGPTL4 mRNA expression (Table 2).
Table 3 gives the abundance of ANGPTL4 mRNA within the main factors.
These results suggested that the ovine ANGPTL4 gene expressed more in shallow than in deep fat depots.
Figure 2 lists the observed and predicted relative expressions of ANGPTL4 mRNA in adipose tissues of Small Tailed Han sheep.
Researchers found that changes in the DNA code which alters a gene called ANGPTL4 are linked to a reduced risk of CHD.