ANGPTL4

ANGPTL4

A gene on chromosome 19p13.3 that encodes angiopoietin-like protein 4, which is expressed in endothelial cells in response to hypoxia. It is directly involved in regulating glucose homeostasis, lipid metabolism and insulin sensitivity; it may act as a regulator of angiogenesis and modulate tumourigenesis, and may protect endothelial cells by secreted factors. It reduces endothelial cell motility and inhibits sprouting and tube formation.
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The ANGPTL4 mutation was linked to lower risk of Type 2 diabetes.
To verify these candidate genes, we performed real-time PCR to detect mRNA change dynamics of ANGPTL4 , NDRG1 , LRP1 , PLIN2 , and so on.
Using data from VAs Million Veteran Program (MVP), the researchers found that three genes PDE3B, PCSK9 and ANGPTL4 could be targets for treatment of heart disease, abdominal aortic aneurysm and diabetes, respectively.
Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion.
However, the majority of the DEGs associated with immune response, proliferation, and cytokine networks, were suppressed in both DON and ZEN dietary treatment groups, including interleukin 10 receptor beta (IL10RB), chemokine (C-X-C motif) ligand 9 (CXCL9), chemo kine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-C motif) ligand 4 (CCL4), [alpha]-aminoadipic semialdehyde dehydrogenase (ALDH7A1), complement component 4 binding protein alpha (C4BPA), insulin-like growth factor binding protein 4, oligoadenylate synthetase 2 (OAS2), receptor-type tyrosine-protein phosphatase C (PTPRC), IgH, angiopoietin-like 4 (ANGPTL4), pyruvate dehydrogenase kinase, isozyme 4, and signaling lymphocytic activation molecule-9.
Lapez-Bermejo et al., "Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazoneflutamide-metformin for adolescent girls with androgen excess: Divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN Expression in subcutaneous adipose tissue," The Journal of Clinical Endocrinology & Metabolism, vol.
Corvera, "Enhanced angiogenesis in obesity and in response to PPAR[gamma] activators through adipocyte VEGF and ANGPTL4 production," American Journal of Physiology-Endocrinology and Metabolism, vol.
Hepatic ANGPTL4 is activated by ligands of PPAR-[alpha], which includes PUFA [3, 7].
Nishimura et al., "Angiopoietinlike protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells," Acta Ophthalmologica, vol.
In this article, we report that Chi preferentially induced two important PPAR target genes, ANGPTL4 (angiopoietin-like 4) and PDK4 (pyruvate dehydrogenase kinase, isozyme 4), which are involved in lipid metabolism and insulin sensitization, relative to Ros and Pio.
Gene Fold upregulation Significance (all time points) FRZB 256.9 *** OMD 72.4 *** PDGFRL 55.7 *** LEPR 29.2 *** IGF2 22.6 *** NGFR 19.6 * MSX1 10.4 ** ANGPTL4 8.2 *** MT2A 7.7 *** SFRP1 7.3 *** TGFBR2 5.7 *** TGFBR3 5.7 *** SPP1 5.5 *** ALPL 4.9 *** SORT1 4.4 *** DVL2 3.2 *** PDGFRA 3.2 *** BMPER 2.8 ** S1PR1 2.8 *** FZD1 2.7 *** CSPG4 2.6 *** FZD4 2.5 *** NGFRAP1 2.4 *** FGFR1 2.1 *** SOX9 0.5 ** NES 0.4 ** VEGFA 0.3 *** SFRP4 0.2 ** Only genes with significant >2-fold induction: * p < 0.05, ** p < 0.01, *** p < 0.001, and *** p < 0.0001.