mutation was linked to lower risk of Type 2 diabetes.
To verify these candidate genes, we performed real-time PCR to detect mRNA change dynamics of ANGPTL4
, NDRG1 , LRP1 , PLIN2 , and so on.
Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4
promotes venous invasion.
However, the majority of the DEGs associated with immune response, proliferation, and cytokine networks, were suppressed in both DON and ZEN dietary treatment groups, including interleukin 10 receptor beta (IL10RB), chemokine (C-X-C motif) ligand 9 (CXCL9), chemo kine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-C motif) ligand 4 (CCL4), [alpha]-aminoadipic semialdehyde dehydrogenase (ALDH7A1), complement component 4 binding protein alpha (C4BPA), insulin-like growth factor binding protein 4, oligoadenylate synthetase 2 (OAS2), receptor-type tyrosine-protein phosphatase C (PTPRC), IgH, angiopoietin-like 4 (ANGPTL4
), pyruvate dehydrogenase kinase, isozyme 4, and signaling lymphocytic activation molecule-9.
Lapez-Bermejo et al., "Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazoneflutamide-metformin for adolescent girls with androgen excess: Divergent effects on CD163, TWEAK receptor, ANGPTL4
, and LEPTIN Expression in subcutaneous adipose tissue," The Journal of Clinical Endocrinology & Metabolism, vol.
Another promising adipokine is angiopoietin-like protein 4 (ANGPTL4
), a multifunctional signal protein expressed in many tissues.
Corvera, "Enhanced angiogenesis in obesity and in response to PPAR[gamma] activators through adipocyte VEGF and ANGPTL4
production," American Journal of Physiology-Endocrinology and Metabolism, vol.
is activated by ligands of PPAR-[alpha], which includes PUFA [3, 7].
Nishimura et al., "Angiopoietinlike protein 4 (ANGPTL4
) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells," Acta Ophthalmologica, vol.
In this article, we report that Chi preferentially induced two important PPAR target genes, ANGPTL4
(angiopoietin-like 4) and PDK4 (pyruvate dehydrogenase kinase, isozyme 4), which are involved in lipid metabolism and insulin sensitization, relative to Ros and Pio.
Gene Fold upregulation Significance (all time points) FRZB 256.9 *** OMD 72.4 *** PDGFRL 55.7 *** LEPR 29.2 *** IGF2 22.6 *** NGFR 19.6 * MSX1 10.4 ** ANGPTL4
8.2 *** MT2A 7.7 *** SFRP1 7.3 *** TGFBR2 5.7 *** TGFBR3 5.7 *** SPP1 5.5 *** ALPL 4.9 *** SORT1 4.4 *** DVL2 3.2 *** PDGFRA 3.2 *** BMPER 2.8 ** S1PR1 2.8 *** FZD1 2.7 *** CSPG4 2.6 *** FZD4 2.5 *** NGFRAP1 2.4 *** FGFR1 2.1 *** SOX9 0.5 ** NES 0.4 ** VEGFA 0.3 *** SFRP4 0.2 ** Only genes with significant >2-fold induction: * p < 0.05, ** p < 0.01, *** p < 0.001, and *** p < 0.0001.