ANGPTL3

ANGPTL3

A gene on chromosome 1p31.1-p22.3 that encodes angiopoietin-like protein 3, which is expressed primarily in the liver.

Molecular pathology
ANGPTL3 mutations are associated with familial hypobetalipoproteinaemia type 2.
References in periodicals archive ?
People with a variant of the ANGPTL3 gene metabolize triglycerides in their blood so efficiently that they are virtually immune to heart disease.
ANGPTL3 regulates lipid and possibly general metabolism through actions in the liver, gut, muscle, and adipose tissue, said Sotirios Tsimikas, MD, in an interview viewable on familypracticenews.
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin avp3 and induces blood veddel formation in vivo.
Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4.
Exome sequencing, ANGPTL3 mutations, mutations, and familial combined hypolipidemia.
I am excited to play a role in Akcea's dedication to advance its promising drugs targeting these poorly addressed lipid risk factors, which include APOCIII, Lp(a) and ANGPTL3, to patients who need these medicines most.
Familial hypocholesterolemia has received recent attention with the identification of mutations in the ANGPTL3 [2] (angiopoietin-like 3) and PCSK9 (proprotein convertase subtilisin/kexin type 9) genes as novel causes of low cholesterol concentrations (2).
2] Human genes: ANGPTL3, angiopoietin-like 3; PCSK9, proprotein convertase subtilisin/kexin type 9.
These data provide solid support for the therapeutic potential of ANGPTL3 to reduce multiple lipid risk factors in patients with cardiovascular disease and to affect liver fat accumulation in patients with NASH," said Dr.
Subjects who received multiple doses of 10 mg, 20 mg, 40 mg, or 60 mg of IONIS-ANGPTL3-LRx achieved dose-dependent, statistically significant mean reductions at Day 37 in ANGPTL3 of up to 83 percent (p ?
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.
ANGPTL3 acts as an inhibitor of lipoprotein lipase and endothelial lipase, and appears to play a central role in lipoprotein metabolism.