I am excited to play a role in Akcea's dedication to advance its promising drugs targeting these poorly addressed lipid risk factors, which include APOCIII, Lp(a) and ANGPTL3, to patients who need these medicines most.
Familial hypocholesterolemia has received recent attention with the identification of mutations in the ANGPTL3  (angiopoietin-like 3) and PCSK9 (proprotein convertase subtilisin/kexin type 9) genes as novel causes of low cholesterol concentrations (2).
2] Human genes: ANGPTL3, angiopoietin-like 3; PCSK9, proprotein convertase subtilisin/kexin type 9.
These data provide solid support for the therapeutic potential of ANGPTL3 to reduce multiple lipid risk factors in patients with cardiovascular disease and to affect liver fat accumulation in patients with NASH," said Dr.
Subjects who received multiple doses of 10 mg, 20 mg, 40 mg, or 60 mg of IONIS-ANGPTL3-LRx achieved dose-dependent, statistically significant mean reductions at Day 37 in ANGPTL3 of up to 83 percent (p ?