ANGPTL2


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ANGPTL2

A gene on chromosome 9q34 that encodes angiopoietin-like protein 2, which induces sprouting in endothelial cells through an autocrine and paracrine actions. It is broadly expressed in heart, small intestine, spleen and stomach. ANGPTL2 has also previously been used for ANGPTL4.
References in periodicals archive ?
Oike, "Diverse roles of ANGPTL2 in physiology and pathophysiology," Trends in Endocrinology and Metabolism, vol.
Zheng et al., "A motif in LILRB2 critical for Angptl2 binding and activation," Blood, vol.
Endo et al., "Mice deficient in angiopoietin-like protein 2 (Angptl2) gene show increased susceptibility to bacterial infection due to attenuated macrophage activity," The Journal of Biological Chemistry, vol.
Miyata et al., "Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Kadomatsu et al., "Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis," Cancer Research, vol.
Nakano et al., "Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis," The International Journal of Biological Markers, vol.
Fang et al., "ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma," Journal of Gastroenterology and Hepatology, vol.
Shitara et al., "Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer," Oncology Letters, vol.
Sosner et al., "ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients," Diabetologia, vol.
Yang et al., "Serum Angptl2 levels are independently associated with albuminuria in type 2 diabetes," Diabetes Research and Clinical Practice, vol.
Turcot et al., "Lower methylation of the ANGPTL2 gene in leukocytes from post-acute coronary syndrome patients," PLoS One, vol.