ANGPTL1

ANGPTL1

A gene on chromosome 1q25.2 that encodes angiopoietin-like protein 1, which is highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine.
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ANGPTL1 is mostly detected in liver, heart, skeletal muscle, kidney, and vessel-rich endocrine organs (adrenal glands, thyroid, and pituitary gland) but also to a lesser extent in uterus and gastrointestinal tract [48].
Glycosylation sites (N) are shown at positions 92, 122, 154, 243, and 295 for ANG1; positions 160 and 188 for ANGPTL1; and position 177 for ANGPTL4.
DE genes Samples Upregulated Downregulated C versus Pcdhgb2 Ubd, Ttr, M [intersection] F Cxcl9, Serpina3n, versus Irg1, Odf1, Trpv4 M [intersection] A versus M F versus Ifit1, AABR06089930.1, M [intersection] C LOC100912860 Cd80, versus M Tfec, Il1rn A versus Alas2, Plac8, C3, M [intersection] C Angptl1, Bcl2a1, S100a4, versus M Cndp1 Il15ra, Ptprcap, Lgals3, Ccl2, LOC691141, Ptx3, Itgal, Pram1, Hk3, Pate4, A2m F versus Ada, Hsf5, Rn50_1_2682.1, M [intersection] A Slc16a12 Cd22 versus M Table 3: Common significant GO terms for DE genes.
Primer sequences were designed in the laboratory and synthesized by Generay Biotech (PRC) based on the mRNA sequences obtained from the National Center for Biotechnology Information (NCBI) database and noncoding RNA sequences obtained from the NCBI database, as follows: 5'-AGTCTCACAGTGTCTTTAACTC-3' for ANGPTL1; 5'- TTAAATCATGGCCCACCTTAC-3' for matrix Gla Protein (MGP); 5'-CTCTGCCGGACATACAAG-3' for FAT1; 5'- GTCAAGAGCACCATAACCT-3' for FABP4; 5'- CACATGGACTGAATCACATAGA-3' for COLEC12; 5'- TATAACAAGGCCACTGAAGATG-3' for CST2; 5'- TGTCTGCTGTGTGTTTGT-3' for OGN; 5'-AGCGGTAGTAACTTTGTGT-3' for n335562; 5'- TAGTGACCGTAATGCACCTT-3' for n337481.
The first group included genes that were randomly chosen, namely COLEC12, fatty acid binding protein 4 (FABP4), ANGPTL1, n337481, and OGN.
The 1q25 probe contains sequences extending from a point telomeric to the WI-6848 locus, through the ABL2 and ANGPTL1 genes, and ending proximally near SHGC-1322.