Australian National Blood Pressure study 2. A trial comparing ACE inhibitors to diuretics in treating hypertension in the elderly. Conclusion ACEIs were no better than diuretics in managing hypertension.
ANBP2 randomized hypertensive patients to initial treatment with an ACE inhibitor (n = 3044) or a diuretic (n = 3039).
Thus ANBP2 actually confirms the results from ALLHAT by showing that ACE inhibitors and diuretics are equivalent in reducing cardiovascular events in hypertension.
(4-8,10,11,13-17) Of the remaining 2 trials, the difference in ANBP2 just reached a P value of .05, while the result in LIFE was driven by a lower stroke incidence on ARB treatment that is not noted in any of the other studies involving an ARB or ACE inhibitor.