AMPA receptor

(redirected from AMPA receptor trafficking)

AMPA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and acts as a cation channel.
Synonym(s): quisqualate receptor
Farlex Partner Medical Dictionary © Farlex 2012

AMPA receptor

A member of the ionotropic class of glutamate receptors (which includes NMDA and kainate receptors).

Functions
Mediate fast excitatory synaptic transmission in the CNS; play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD).

Structure
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those with a GluR2 subunit have low permeability to Ca2+; those lacking a GluR2 subunit have high Ca2+ permeability.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

AMPA receptor

Neurophysiology Any of a family of distinct ionotropic glutamate–excitatory post-synaptic receptors widely expressed in the CNS, which are the 1º memory receptors. See Excitatory amino acid receptor channel, Glutamate receptor.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Roche, "Posttranslational regulation of AMPA receptor trafficking and function," Current Opinion in Neurobiology, vol.
Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System
TNF[alpha] is also a critical component of the regulatory system controlling synaptic plasticity [121], synaptic strength, and excitability by modifying AMPA receptor trafficking. This occurs through a deficiency of GluR2 with a consequent increase in [Ca.sup.2+] permeability [122].
Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNF[alpha]
Zheng, "Inhibition of AMPA receptor trafficking at hippocampal synapses by amyloid oligomers: the mitochondrial contribution," Molecular Brain, vol.
Letrozole potentiates mitochondrial and dendritic spine impairments induced by [beta] amyloid
Topics include AMPA receptor trafficking, long-term plasticity at inhibitory synapses, proteomics of the PSD, phosphorylation of site-specific antibodies, protein palmitoylation by the DHHC protein family, antibody labeling and biotinylation approaches to study neurotransmitter receptors, visualization of AMPAR trafficking and surface expression, neurotransmitter dynamics, receptors dynamics and functional tagging, RNAi and applications in neurobiology, transfecting and transducing neurons, expression of recombinant proteins in rat brains using Sindbus virus, Lentivirus-based genetic manipulation, AMPA receptor phosphorylation in synaptic plasticity, and genomic and post-genomic tools for studying synapse biology.
The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology
This result is inconsistent with the idea that sensitization-induced facilitation of the sensorimotor synapse is mediated primarily by enhanced presynaptic release; further, it supports the involvement of AMPA receptor trafficking in sensitization.
The cellular mechanisms of learning in Aplysia: of blind men and elephants
Nicoll, "AMPA receptor trafficking at excitatory synapses," Neuron, vol.
Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts
Malinow, "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons," Cell, vol.
Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity
PICK-1 is important in AMPA receptor trafficking during long-term synaptic plasticity [12, 13].
Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission
In addition to inhibiting glutamate release, riluzole increases glutamate reuptake, blocks NMDA receptor activity, and increases AMPA receptor trafficking [3].
New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity
Zheng, "AMPA receptor trafficking and learning," The European Journal of Neuroscience, vol.
Endophilin2 Interacts with GluAl to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-[beta]
Sheng, "Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD," Neuron, vol.
Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins
Further studies are needed to provide a more comprehensive picture of the mechanism and role of AMPA receptor trafficking in hippocampal LTP.
Ionotropic glutamate receptors and voltage-gated [Ca.sup.2+] channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity

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