Roche, "Posttranslational regulation of AMPA receptor trafficking
and function," Current Opinion in Neurobiology, vol.
TNF[alpha] is also a critical component of the regulatory system controlling synaptic plasticity , synaptic strength, and excitability by modifying AMPA receptor trafficking
. This occurs through a deficiency of GluR2 with a consequent increase in [Ca.sup.2+] permeability .
Zheng, "Inhibition of AMPA receptor trafficking
at hippocampal synapses by amyloid oligomers: the mitochondrial contribution," Molecular Brain, vol.
Topics include AMPA receptor trafficking
, long-term plasticity at inhibitory synapses, proteomics of the PSD, phosphorylation of site-specific antibodies, protein palmitoylation by the DHHC protein family, antibody labeling and biotinylation approaches to study neurotransmitter receptors, visualization of AMPAR trafficking and surface expression, neurotransmitter dynamics, receptors dynamics and functional tagging, RNAi and applications in neurobiology, transfecting and transducing neurons, expression of recombinant proteins in rat brains using Sindbus virus, Lentivirus-based genetic manipulation, AMPA receptor phosphorylation in synaptic plasticity, and genomic and post-genomic tools for studying synapse biology.
This result is inconsistent with the idea that sensitization-induced facilitation of the sensorimotor synapse is mediated primarily by enhanced presynaptic release; further, it supports the involvement of AMPA receptor trafficking
Nicoll, "AMPA receptor trafficking
at excitatory synapses," Neuron, vol.
Malinow, "Subunit-specific rules governing AMPA receptor trafficking
to synapses in hippocampal pyramidal neurons," Cell, vol.
PICK-1 is important in AMPA receptor trafficking
during long-term synaptic plasticity [12, 13].
In addition to inhibiting glutamate release, riluzole increases glutamate reuptake, blocks NMDA receptor activity, and increases AMPA receptor trafficking
Zheng, "AMPA receptor trafficking
and learning," The European Journal of Neuroscience, vol.
Sheng, "Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking
and hippocampal LTD," Neuron, vol.
Further studies are needed to provide a more comprehensive picture of the mechanism and role of AMPA receptor trafficking
in hippocampal LTP.