AMPA receptor

(redirected from AMPA receptor trafficking)

AMPA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and acts as a cation channel.

AMPA receptor

A member of the ionotropic class of glutamate receptors (which includes NMDA and kainate receptors).

Functions
Mediate fast excitatory synaptic transmission in the CNS; play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD).

Structure
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those with a GluR2 subunit have low permeability to Ca2+; those lacking a GluR2 subunit have high Ca2+ permeability.

AMPA receptor

Neurophysiology Any of a family of distinct ionotropic glutamate–excitatory post-synaptic receptors widely expressed in the CNS, which are the 1º memory receptors. See Excitatory amino acid receptor channel, Glutamate receptor.
References in periodicals archive ?
Roche, "Posttranslational regulation of AMPA receptor trafficking and function," Current Opinion in Neurobiology, vol.
TNF[alpha] is also a critical component of the regulatory system controlling synaptic plasticity [121], synaptic strength, and excitability by modifying AMPA receptor trafficking. This occurs through a deficiency of GluR2 with a consequent increase in [Ca.sup.2+] permeability [122].
Zheng, "Inhibition of AMPA receptor trafficking at hippocampal synapses by amyloid oligomers: the mitochondrial contribution," Molecular Brain, vol.
Topics include AMPA receptor trafficking, long-term plasticity at inhibitory synapses, proteomics of the PSD, phosphorylation of site-specific antibodies, protein palmitoylation by the DHHC protein family, antibody labeling and biotinylation approaches to study neurotransmitter receptors, visualization of AMPAR trafficking and surface expression, neurotransmitter dynamics, receptors dynamics and functional tagging, RNAi and applications in neurobiology, transfecting and transducing neurons, expression of recombinant proteins in rat brains using Sindbus virus, Lentivirus-based genetic manipulation, AMPA receptor phosphorylation in synaptic plasticity, and genomic and post-genomic tools for studying synapse biology.
This result is inconsistent with the idea that sensitization-induced facilitation of the sensorimotor synapse is mediated primarily by enhanced presynaptic release; further, it supports the involvement of AMPA receptor trafficking in sensitization.
Malinow, "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons," Cell, vol.
PICK-1 is important in AMPA receptor trafficking during long-term synaptic plasticity [12, 13].
In addition to inhibiting glutamate release, riluzole increases glutamate reuptake, blocks NMDA receptor activity, and increases AMPA receptor trafficking [3].
Zheng, "AMPA receptor trafficking and learning," The European Journal of Neuroscience, vol.
Sheng, "Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD," Neuron, vol.
Further studies are needed to provide a more comprehensive picture of the mechanism and role of AMPA receptor trafficking in hippocampal LTP.