AMPA receptor


Also found in: Wikipedia.

AMPA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and acts as a cation channel.

AMPA receptor

A member of the ionotropic class of glutamate receptors (which includes NMDA and kainate receptors).

Functions
Mediate fast excitatory synaptic transmission in the CNS; play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD).

Structure
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those with a GluR2 subunit have low permeability to Ca2+; those lacking a GluR2 subunit have high Ca2+ permeability.

AMPA receptor

Neurophysiology Any of a family of distinct ionotropic glutamate–excitatory post-synaptic receptors widely expressed in the CNS, which are the 1º memory receptors. See Excitatory amino acid receptor channel, Glutamate receptor.
References in periodicals archive ?
The product, which is ready for phase 2b development, is an AMPA receptor potentiator, developed for treating cognitive impairment associated with schizophrenia.
Biogen (BIIB) announced an agreement to acquire from Pfizer (PFE) a Phase 2b ready AMPA receptor potentiator for cognitive impairment associated with schizophrenia.
NYSE: PFE) PF-04958242, a first-in-class, Phase 2b ready AMPA receptor potentiator for cognitive impairment associated with schizophrenia, the company said.
A highly selective, noncompetitive AMPA receptor antagonist that reduces neuronal hyperexcitation associated with seizures by targeting glutamate activity at postsynaptic AMPA receptors, it is approved in countries around the world as an adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures, and primary generalized tonic-clonic seizures in patients with epilepsy 12 years of age and older.
sup][73],[88] Perampanel, a selective AMPA receptor antagonist, however, failed to effect statistically significant improvement in motor symptoms and motor fluctuations of levodopa-treated patients with moderately advanced PD in clinical trials.
GRIP1 can directly interact with and control kinesin heavy chains in dendrites as a motor for the AMPA receptor [15].
Abbreviations: PNS: peripheral nervous system; NMJ: neuromuscular junction; CNS: central nervous system; EM: electron microscopy; FIB-SEM: focused ion beam/scanning electron microscopy; GFP: green fluorescent protein; PSD: postsynaptic density; NMDA: N-methyl-D-aspartic acid; AMPA: a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; TARP: transmembrane AMPA receptor regulatory protein; ASD: autism spectrum disorder; CNV: copy number variation; IEG: immediately early gene; FRAP: fluorescence recovery after photobleaching; GKAP: guanylate kinase-associated protein; LRRTM: leucinerich repeat transmembrane protein; SALM: synaptic adhesion-like molecule; YFP: yellow fluorescent protein; CFP: cyan fluorescent protein.
The current could be blockaded by the selective NMDA receptor antagonist, 2-amino-5-phosphonovalerate/pharmacology (APV, Sigma-Aldrich) and selective AMPA receptor antagonist, 6,7-dinitro-quinoxaline-2,3(1H,4H)dione (DNQX, Sigma-Aldrich), indicating that the recorded current was mEPSCs mediated by the glutamatergic receptor (figure 3A).
It is a highly selective, noncompetitive AMPA receptor antagonist that reduces neuronal hyperexcitation associated with seizures by targeting glutamate activity at postsynaptic AMPA receptors.
At first glance, these two forms of LTD appear to be the same, because they both are mediated via Gq signaling and appear to result from postsynaptic AMPA receptor trafficking.
With the removal of magnesium block, NMDA receptors, which are colocalised with AMPA receptor, become activated.
Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic longterm potention.