announced today that the latest data on its in-house developed AMPA receptor
antagonist Fycompa (perampanel hydrate, perampanel) will be presented at the 69th American Epilepsy Society (AES) Annual Meeting to be held from December 4 to 8 in Philadelphia in the United States.
Because these receptors are so similar in structure, it was assumed that they function in much the same way, but when we altered the dimer interface, the site where two subunits come together within each pair, we found that the NMDA receptor works just the opposite of the way that the AMPA receptor
works," points out Popescu.
Researchers have found increases, decreases, and no change in NMDA and/or AMPA receptor
subunit levels (for examples see Dettmer et al.
A sampling of topics: neurochemical and developmental aspects of glutamate receptors in the retina, insights from structure-function studies of AMPA receptor
agonists and competitive antagonists, NMDA receptor-mediated activation of arachidonic acid and nitric oxide signaling pathways in the spinal processing of pain, AMPA receptor
-mediated neuronal death in motor neuron disease, excitotoxicity and white matter damage, and chemoreception of umami in caterpillars.
These target the function of a molecule in the brain called the AMPA receptor
, thought to help us form memories.
Here, we questioned whether glutamate acts selectively at NMDA receptors to elicit feeding or whether it also acts at the AMPA receptor
207) It is feasible that the infusion of antisense oligonucleotides targeted to certain genes in a cell-death signal pathway might also be effective in vivo because infused antisense oligonucleotides targeted to the GluR2 AMPA receptor
have been shown to modify synaptic excitatory transmission in the cochleae of guinea pigs.
In animal models, neuroprotective agents, known as glutamate antagonists, minimize brain cell death by inhibiting glutamate release, or blocking glutamate binding at NMDA or AMPA receptor
Cortex Pharmaceuticals has developed a class of compounds called AMPA receptor
modulators, which enhance the glutamate-based transmission between brain cells.
A PHASE I TRIAL OF BRIEF INTRAVENOUS INFUSION OF THE AMPA RECEPTOR
BLOCKER LY293558 TO EXAMINE SAFETY AND EFFECTS OF PAIN PERCEPTION IN NORMAL VOLUNTEERS.
In New Zealand, the patent office has given Cortex a notice of allowance for a patent entitled, "Benzofurazan Compounds which Enhance AMPA Receptor
CX1739, an AMPA receptor
positive allosteric modulator (AMPA PAM), is a Phase 2 oral drug product.