With epileptic seizures being mediated by the neurotransmitter glutamate, the agent is a highly selective, noncompetitive AMPA receptor
antagonist that reduces neuronal hyperexcitation by targeting glutamate activity at AMPA receptors
on postsynaptic membranes.
They used a chemical tag to watch how key "AMPA" receptors changed in the synapses and saw that synaptic enlargement and strengthening correlated with more AMPA receptor
expression while shrinking and weakening correlated with less AMPA receptor
Edonerpic maleate helps this process by facilitating the delivery of an important neurotransmitter receptor, called AMPA receptor
, to the structures called synapses, which mediate information between neurons.
FYCOMPA, which is the first and only seizure medication that targets the AMPA receptor
, was initially approved for adjunctive use in patients with POS and PGTC seizures, as a monotherapy use for the treatment of patients with POS as well as an oral suspension formulation.
The product, which is ready for phase 2b development, is an AMPA receptor
potentiator, developed for treating cognitive impairment associated with schizophrenia.
Biogen (BIIB) announced an agreement to acquire from Pfizer (PFE) a Phase 2b ready AMPA receptor
potentiator for cognitive impairment associated with schizophrenia.
Target: PF-0495824, an AMPA receptor
potentiator for cognitive impairment associated with schizophrenia
 found that the knockdown of NL1 in developing neurons in the optic tectum of Xenopus laevis tadpoles led to a decrease in synapse densities and AMPA receptor
Since all three AEDs have an inhibiting effect on glutamatergic transmission via the AMPA receptor
, it appears most promising for future research to focus on this mechanism .
GRIP1 can directly interact with and control kinesin heavy chains in dendrites as a motor for the AMPA receptor
Abbreviations: PNS: peripheral nervous system; NMJ: neuromuscular junction; CNS: central nervous system; EM: electron microscopy; FIB-SEM: focused ion beam/scanning electron microscopy; GFP: green fluorescent protein; PSD: postsynaptic density; NMDA: N-methyl-D-aspartic acid; AMPA: a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; TARP: transmembrane AMPA receptor
regulatory protein; ASD: autism spectrum disorder; CNV: copy number variation; IEG: immediately early gene; FRAP: fluorescence recovery after photobleaching; GKAP: guanylate kinase-associated protein; LRRTM: leucinerich repeat transmembrane protein; SALM: synaptic adhesion-like molecule; YFP: yellow fluorescent protein; CFP: cyan fluorescent protein.