AMP deaminase

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AMP de·am·i·nase

An enzyme that hydrolyzes adenylic acid to inosinic acid and NH3. A muscular deficiency of AMP deaminase in muscles can lead to excess fatigue following exercise.
References in periodicals archive ?
The net effect of this inhibition is the accumulation of AICAR and its metabolites, which are inhibitors of adenosine deaminase and AMP deaminase.
The assay for AMP deaminase activity from skeletal muscle was determined in accordance with the following steps [3].
AMP deaminase deficiency in skeletal muscle is unlikely to be of clinical relevance.
A genese do AMP, que envolve a acao da AMP deaminase, ocorre quando a utilizacao do ATP excede a capacidade celular para a sua ressintese (Murray e Colaboradores, 2003).
Diversos autores corroboram essa analise (Graham e Colaboradores, 1997; Wagenmakers, 1998, Bassini-Cameron e Colaboradores, 2008), quando afirmam que individuos treinados apresentam menor elevacao da amonemia quando comparados com nao treinados, ou treinados em atividades anaerobias (Yuan e Colaboradores, 2002), fato explicado possivelmente pela reducao da atividade das enzimas AMP deaminase e glutamato desidrogenase.
IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment.
2 [Aspergillus nidulans FGSC A4] (3e-26) Beta-xylosidase, putative [Penicillium marneffei ATCC 18224] (1e-21) 26B 52 Hypothetical protein An03g06970 [Aspergillus niger] (0) AMP deaminase Amd1 [Aspergillus fumigatus Af293] (0) Hypothetical protein [Aspergillus oryzae RIB40] (0) AMP deaminase [Aspergillus terreus NIH2624] (0) Searched/ matched spot peptides Sequence coverage 3B 19/8 20% 4B 18/5 11% 9B 12/5 17% 10B 9/4 11% 25B 8/3 26% 26B 5/5 6% Table 2.
oryzae (E value= 0) and with AMP deaminases of both A.
AMP is usually deaminated in most tissues by AMP deaminase and, to a lesser extent, by the ADA degradation pathway.
Dale's rabbit studies also showed that the amount of AMP deaminase, an enzyme that degrades a component of ATP, declines in older red cells -- a finding since confirmed in human red cells.