RUNX1

(redirected from AML1-EVI-1 fusion protein)

RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in classic literature ?
If the reverend fathers,'' he said, ``loved good cheer and soft lodging, few miles of riding would carry them to the Priory of Brinxworth, where their quality could not but secure them the most honourable reception; or if they preferred spending a penitential evening, they might turn down yonder wild glade, which would bring them to the hermitage of Copmanhurst, where a pious anchoret would make them sharers for the night of the shelter of his roof and the benefit of his prayers.
I have seen the first monks and anchorets, without crossing seas or centuries.