RUNX1

(redirected from AML1)
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RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in periodicals archive ?
NSA has provided a summary of the changes: You must swap from the old AML1 form to the new ARAMS form and send it to SouthWestern instead of your local authority.
In our study, partial SSU rDNA of AMF colonizing trifoliate orange and red tangerine was successfully amplified by the primer pairs AML1 and AML2.
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.
Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;21)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML.
It is noted that VYXEOS is the first product candidate to exhibit a statistically significant improvement in Overall Survival in patients with high-risk (secondary) AML1.
As a result the paper movement licence (AML1 forms) that were historically sent to local Trading Standards offices should now be sent to the EIDCymru office in Aberystwyth.
AML1 regulates myelopoiesis by recruiting chromatin remodeling enzymes on pre-miR-223 gene and silencing cell differentiation [119].
Therefore rather than posting the current AML1 form to their local authority, farmers will instead post the new movement document to the SouthWestern bureau.
(Months) (Months) probability Error for of RFS RFS AML1 No treatment NA * AML2 No treatment NA AML3 1 6.2 0.635 0.169 AML4 1.3 15.9 0 NA AML5 1.8 8.6 AML6 1.2 10.8 AML7 1 14.9 0.317 0.24 AML8 1.6 7.1 AML9 NA NA AML10 2.1 3.4 0.889 0.105 AML11 1.1 5.6 AML12 2.3 5.8 0.762 0.148 Patient 95% OS Survival Standard No.
"Farmers can obtain copies of the new AML1 forms from their local authority."
t(8;21) fuses the N-terminal, DNA-binding domain of AML1 (RUNX1) to a virtually complete MTG8 fragment, inducing a broad dysregulation of AML1 target genes in preleukemic clones [4-6].