AMBRA1

AMBRA1

A gene on chromosome 11p11.2 that encodes a protein involved in regulating autophagy by controlling protein turnover during neuronal development, as well as in regulating normal cell survival and proliferation.
References in periodicals archive ?
Targeted overexpression of AMBRA1 at the mitochondrial outer membrane induces autophagy in both Parkin-dependent and Parkin-independent ways [239].
Mitophagy in a Parkin-independent way (lower right) may also occur since (a) the autophagy receptors NIX and BNIP3 can directly interact with the autophagosome through the LC3 receptor; (b) AMBRA1 if overexpressed in the mitochondria outer membrane interacts with the LC3 receptor and can induce autophagy by both Parkin dependent and Parkin-independent pathways; and (c) PINK1 phosphorylates the ubiquitin chains in mitochondria promoting the recruitment of NDP52 [also known as Calcium binding and Coil-Coil domain protein 2, (CALCOCO2)] and optineurin autophagy receptors; subsequently, ND52 and optineurin recruit the upstream machinery of autophagy and trigger mitophagy.