AMBP


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AMBP

A gene on chromosome 9q32-q33 that encodes alpha-1-microglobulin/bikunin precursor protein, which is expressed in liver and secreted in plasma. Alpha-1-microglobulin belongs to the superfamily of lipocalin transport proteins and plays a role in regulating inflammation; bikunin belongs to the superfamily of Kunitz-type protease inhibitors and plays a key role in many physiological and pathological processes, by inhibiting trypsin, plasmin and lysosomal granulocytic elastase, as well as calcium oxalate crystallisation.
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Interestingly, in our findings plasma APR proteins (i.e., AMBP, HPT, FIBB, A1AT, and CO3) are five out of six (i.e., 83.3%) of the overexpressed proteins found in the classical sisters as compared with the PSV ones.
Three other genes, transferrin, AMBP, and [beta]-actin, appeared to decrease in a dose-dependent manner (Figure 6B).
In the renal cortex they confirmed differences in expression of apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), alpha-1-microglobulin/bikunin precursor (AMBP), apolipoprotein E (APOE), cluster of differentiation 36 (CD36), ephrin-B1 (EFNB1), NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 (NDUFAF1), peroxiredoxin 5 (PRDX5), REN, renin binding protein (RENBP), solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1), syntaxin 4 (STX4), and troponin T type 2 (cardiac) (TNNT2) mRNAs, and the miRNAs hsa-miR-21, hsa-miR-126, hsa-miR-181a, hsa-miR-196a, hsamiR-451, hsa-miR-638, and hsa-miR-663.