AMACR


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AMACR

Alpha-Methylacyl coenzyme A racemase. An enzyme involved in beta-oxidation of branched-chain fatty acids, the gene for which is overexpressed in certain cancers, in particular prostate.

AMACR

alpha-Methylacyl-CoA racemase.
References in periodicals archive ?
Conclusion: Positive staining for AMACR can be used to support a diagnosis of cancer on prostate needle core biopsies when the focus in question is <1mm in maximum dimension.
The most common adenocarcinomas metastatic to the bladder are from the prostate, therefore, markers PSA (prostate specific antigen) and AMACR (alpha-methylacyl-CoA racemase) which are positive for prostate origin, were performed.
Interpretation of AMACR staining- Positive staining is indicated by brownish cytoplasmic staining of 80-100% of tumour cells in tissue sections.
All prostatic carcinoma showed a red cytoplasmic granular staining pattern of AMACR in the malignant glands and cells, and dark brown nuclear (p63) and cytoplasmic (34[beta]E12) staining in basal cells in the adjacent nonmalignant glands.
The usual phenotype of translocation carcinoma (CK7 -, AMACR +, CD10 +, EMA -) helps separate these from conventional clear cell renal carcinoma (CK7 -, AMACR-, CD10 +, EMA +) and papillary renal cell carcinoma (CK7 +, AMACR +, CD10 +, EMA+) (9,10).
There are studies that shows that the chromosomal region for AMACR (5p13) is the candidate region of gene and AMACR gene polymorphism is frequent in PAs of families that have hereditary PA.
5) AMACR is negative or focally expressed in clear cell RCC, and CD117, TFE3/TFEB, and HMB45 are often negative.
Tumour cells are immunopositive for CK19 (a: x200), vimentin (b: x200), CD10 (c: x400) and AMACR (d: x200).
AMACR breaks down branched-chain fatty acids, a type of molecule only found in animals that eat plants.
Gene Localization annotation prediction SwissProt localization Tissue specificity KLK3 (PSA) Secreted Secreted protein Primarily prostate ACPP Secreted No annotation Primarily prostate VEGF Secreted Secreted protein Ubiquitous FN1 Secreted Secreted protein Ubiquitous ZWINT Not secreted Nucleus Moderatea AMACR Not secreted Peroxisome mitochondrion Ubiquitous HPN Not secreted Type II membrane Moderatea We analyzed 7 genes by the secretion and specificity prediction methods described above.
He and his collaborators have characterized a number of biomarkers of prostate cancer including AMACR, EZH2 and hepsin.
Immunohistochemical Profile of Different Histologic Subtypes of Endometrial Carcinoma Serous Clear Cell Endometrioid p53 +++ or complete -/+++ -/+++ (grade 3) absence ("null") p16 +++ -/+ -/+ (patchy) ER +/- (a) - +++ PR -/+ - ++ HNF-1 [beta] -/+ +++ -/+ Napsin -/+ +++ -/+ AMACR - - Abbreviations: AMACR, a-methylacyl coenzyme A racemase; ER, estrogen receptor; HNF-1 [beta], hepatocyte nuclear factor 1; PR, progesterone receptor; +, weak positivity; ++, moderate positivity; +++, strong positivity; -, negative; -/+: focal or patchy positivity.