ALX4


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ALX4

A gene on chromosome 11p11.2 that encodes a homeodomain transcription factor, which may play a role in craniofacial development, mesenchymal-epithelial communication and hair-follicle development.

Molecular pathology
ALX4 mutations cause parietal foramina 2 and Potocki-Shaffer syndrome.
References in periodicals archive ?
For the present study, we chose well-known genes, regulation regions of which were often hypermethylated at colorectal cancer: SEPT9, FBN1, VIM, SDC2, THBD, SFRP2, ESR1, TMEFF2, NGFR, ALX4, HLTF, and NEUROG1 [20,21].
For example, we can observe such results in literature for SEPT9, ALX4, RASSF1, and some other genes [20,21].
These markers (ALX4, EYA4, FOXL2, and SIX6) will be tested in subsequent studies to evaluate their clinical performance.
Also, other genes have been reported to be highly specific and sensitive cfDNA CRC biomarkers, such as APC, CDKN2A/P16h, MLH1, ALX4, TMEFF2, NGFR, FRP2, NEUROG1, TPEF/HPP1, and RUNX3 [72-74].
The skull, known as Xujiayao 11, has an unusual perforation through the top of the brain case-an enlarged parietal foramen (EPF) or "hole in the skull"-that is consistent with modern humans diagnosed with a rare genetic mutation in the homeobox genes ALX4 on chromosome 11 and MSX2 on chromosome 5.