ALX4


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ALX4

A gene on chromosome 11p11.2 that encodes a homeodomain transcription factor, which may play a role in craniofacial development, mesenchymal-epithelial communication and hair-follicle development.

Molecular pathology
ALX4 mutations cause parietal foramina 2 and Potocki-Shaffer syndrome.
References in periodicals archive ?
The skull, known as Xujiayao 11, has an unusual perforation through the top of the brain case-an enlarged parietal foramen (EPF) or "hole in the skull"-that is consistent with modern humans diagnosed with a rare genetic mutation in the homeobox genes ALX4 on chromosome 11 and MSX2 on chromosome 5.
To achieve this combination of technical sensitivity and specificity, we optimized qPCR assays selected from the tissue studies that used the HM technology [TUSC3, tumor suppressor candidate 3; TMEFF2; ZDHHC22, zinc finger, DHHC-type containing 22; VTN; FOXL2, forkhead box L2; NGFR; ALX4, aristaless-like homeobox 4; SIX6, SIX homeobox 6; EYA4; and SEPT9] (14).