Two significant gene regions from the discovery PM 10-related DMR analyses, including genes H19 and MARCH11, were also FDR-significant in analysis of the ALSPAC
newborn sample using DMRcate (replication min FDR p = 9.5 x [10.sup.-4] and p = 3.9 x [10.sup.-5], respectively).
Data for both time points (during pregnancy and 18 years after) and both subsamples (ARIES and extra samples from ALSPAC
) were preprocessed as a single set in R (version 3.0.1) with the wateRmelon package according to the subset-quantile normalization approach .
Analyses of the ALSPAC
cohort of 12, 944 women in England.
Professor George Davey Smith, co-author and scientific director of ALSPAC
, said: "Many traits that related to disease risk -- like blood pressure or cholesterol levels -- demonstrate a similar continuum of risk, with contributions from common and rare genetic variants, plus environmental and chance events.
Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC
Patterns of alcohol use and multiple risk behaviour by gender during early and late adolescence: the ALSPAC
Carding, P.N., Roulstone, S., & Northstone, K., ALSPAC
Study Team (2006).
Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC
For example, in the Avon Longitudinal Study of Parents and Children (ALSPAC
), sedentary pregnant women were at a greater risk of giving birth to low birth weight babies, than their more active counterparts.
The report was published in The Lancet Psychiatry and is based on the aACAyAvon Longitudinal Study of Parents and Children' (ALSPAC
) in Britain and the aACAyGreat Smoky Mountain Studies' (GSMS) in the United States.
Northstone K, Emmett P, Nethersole F and the ALSPAC