SOD1

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SOD1

A gene on chromosome 21q22.11 that encodes a soluble, copper- and zinc-binding cytoplasmic protein, which is responsible for destroying free superoxide radicals in the body, converting natural—but harmful—superoxide radicals to molecular oxygen and hydrogen peroxide.

Molecular pathology
SOD1 mutations have been linked to familial amyotrophic lateral sclerosis.
References in periodicals archive ?
Loss of proteostasis and dysfunction of the autophagy process, has been closely linked to the pathogenesis of human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and ALS1. The Cells paper also noted that this is the first report to show that Sig-1R activation enhances the autophagic ?ux in human cells and in C.
About 5-10% of ALS cases are inherited and among those about 20% are associated with missense mutations in the ALS1 locus on chromosome 21, which codes for Cu/Zn superoxide dismutase (SOD1) [6].
The primers and PCR conditions used were previously described: ALS1 and ALS3 [17], HWP1 [18], SAP1 [19], SAP4-SAP6 [20], LIP1-LIP10 and PLB1-PLB2 [13], and CDR1 and MDR1 [21] (Table 1).
ASTROLL DOWN THE BEAUTY ALS1.E OF any retailer will reveal many eye-catching packages that convey a specific brand image.
"Als1 to the king's saying: 'Guard yourself,' consider that previously, in the days of my ancestors, there was a garrison of the king with them and property of the king was at their disposal, but as far as I am concerned, there are no provisions of the king at my disiposlal, and there is no garrison of the king with me" (EA 122: 9-18).
The herbicide tolerance carried in FS4 is conditioned by an allele of the Als1 locus for acetolactate synthase with the allele designation Als1fid04.
als1: "if" [ENR, 1_00, +p+c, f_VS] 'Als je je best doet mag je mee op reis.' ('If you do your best, you can come along travelling.')