ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.

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5-LO

References in periodicals archive ?

The researchers also looked at whether a variant in the gene ALOX5 affected study findings.

Fish oil does not appear to improve asthma control in obese youngsters: Study

CSC EMT Therapeutic target X AKT/mTOR signaling pathway X X AKT2 X ALOX5 X Bmi-1 X Bmi-1 X EGR-1 X EGR-1 X EGR-1 X EGR-1 X EGR-1 X Hedgehog signaling X HMGA2 X IAP family X X JAK 1/2 X Kruppel-like factor 5 X Lysine-specific demethylase 1 X mTOR X n.d.

Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells

Immediate-type hypersensitivity to NSAIDs has also been reported to be associated with genes belonging to the arachidonic acid pathway (ALOX5, ALOX5AP, ALOX15, TBXAS1, PTGDR, and CYSLTR1) [72, 78].

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.

Computational Analysis of High Risk Missense Variant in Human UTY Gene: A Candidate Gene of AZFa Sub-region

In addition, the critical metabolic enzymes including PTGS1/2, LTA4H, ALOX5, AKR1C3, and CYP1A2/4 were the system pharmacology targets of BJF.

Integrating Transcriptomics, Proteomics, and Metabolomics Profiling with System Pharmacology for the Delineation of Long-Term Therapeutic Mechanisms of Bufei Jianpi Formula in Treating COPD

Owing to the correlation between eicosanoids and endothelial cancer development (Bogatcheva et al., 2005), the two eicosanoid biosynthetic pathways and signaling receptors were studied, including the key rate-limiting enzymes COXs (COX-1 and COX-2) and LOX (ALOX5), the class-specific terminal synthases--mPGES1, mPGES-2, cPGES, PGFS (alias: AKR1C), PTGDS, HPGDS, PTGIS, TXBA2S and LTC4S, and their respective receptors--[EP.sub.1], [EP.sub.2], [EP.sub.3], [EP.sub.4], FP, DP, IP, CYSLTR1 and CYSLTR2 (see Suppl.

Cytotoxic and pro-oxidative effects of Imperata cylindrica aerial part ethyl acetate extract in colorectal cancer in vitro

Nebohacova et al., "Identification of ALOX5 as a gene regulating adiposity and pancreatic function," Diabetologia, vol.

5-lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte

The omega 3s inhibit the activity of ALOX5, an enzyme that exacerbates lung inflammation and causes asthma.

Asthma patients with specific genotypes identified for fish oil treatment trial

It is well known that 5-lipoxygenase (ALOX5) is a key enzyme in the biosynthesis of leukotrienes from arachidonic acid in inflammatory and allergic processes.

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses

Structural proteins Coactosin-like protein Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.

Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth

Dr, Shaoguang Li, The Jackson Laboratory Adjunct Professor, led a team of researchers who identified a gene, called Alox5, involved with the inflammatory response that could hold the key to treating or even preventing CML.