The researchers also looked at whether a variant in the gene ALOX5
affected study findings.
CSC EMT Therapeutic target X AKT/mTOR signaling pathway X X AKT2 X ALOX5
X Bmi-1 X Bmi-1 X EGR-1 X EGR-1 X EGR-1 X EGR-1 X EGR-1 X Hedgehog signaling X HMGA2 X IAP family X X JAK 1/2 X Kruppel-like factor 5 X Lysine-specific demethylase 1 X mTOR X n.d.
Immediate-type hypersensitivity to NSAIDs has also been reported to be associated with genes belonging to the arachidonic acid pathway (ALOX5
, ALOX5AP, ALOX15, TBXAS1, PTGDR, and CYSLTR1) [72, 78].
Pharmacogenetic association between ALOX5
promoter genotype and the response to anti-asthma treatment.
In addition, the critical metabolic enzymes including PTGS1/2, LTA4H, ALOX5
, AKR1C3, and CYP1A2/4 were the system pharmacology targets of BJF.
Owing to the correlation between eicosanoids and endothelial cancer development (Bogatcheva et al., 2005), the two eicosanoid biosynthetic pathways and signaling receptors were studied, including the key rate-limiting enzymes COXs (COX-1 and COX-2) and LOX (ALOX5
), the class-specific terminal synthases--mPGES1, mPGES-2, cPGES, PGFS (alias: AKR1C), PTGDS, HPGDS, PTGIS, TXBA2S and LTC4S, and their respective receptors--[EP.sub.1], [EP.sub.2], [EP.sub.3], [EP.sub.4], FP, DP, IP, CYSLTR1 and CYSLTR2 (see Suppl.
Nebohacova et al., "Identification of ALOX5
as a gene regulating adiposity and pancreatic function," Diabetologia, vol.
The omega 3s inhibit the activity of ALOX5
, an enzyme that exacerbates lung inflammation and causes asthma.
It is well known that 5-lipoxygenase (ALOX5
) is a key enzyme in the biosynthesis of leukotrienes from arachidonic acid in inflammatory and allergic processes.
Structural proteins Coactosin-like protein Acts as a chaperone for ALOX5
(5LO), influencing both its stability and activity in leukotrienes synthesis.
Dr, Shaoguang Li, The Jackson Laboratory Adjunct Professor, led a team of researchers who identified a gene, called Alox5
, involved with the inflammatory response that could hold the key to treating or even preventing CML.