ALOX12B

ALOX12B

A gene on chromosome 17p13.1 that encodes an enzyme involved in the converting arachidonic acid to 12R-hydroxyeicosatetraenoic acid.

Molecular pathology
ALOX12B mutations are linked to nonbullous congenital ichthyosiform erythroderma.
References in periodicals archive ?
ELOVL6, fatty acid elongase 6; CYP4F22/39, cytochrome P450 family F22 (in human) and F39 (in mouse); CERS3, ceramide synthase 3; ABCA12, ABC transporter 12; UGCG, UDP-glucose ceramide glucosyltransferase; GBA, [beta]-glucocerebrosidase; ALOXE3, epidermal-type lipoxygenase 3; ALOX12B, 12R-lipoxygenase; TGM1, transglutaminase 1.
Self-healing colloidion membrane and mild nonbullous congenital icthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.
6 To date, 6 genes for lamellar ichthyosis have been localized and 5 of them identified, as follows2: TGM1 (14q11), ABCA12 (2q34), 19p12-q12, 19p13, ALOXE3- ALOX12B (17p13), ichthyin (5q33).
Bu genler; ABCAU, NIPAL(ICHTHYIN), CYP4F22, iki lipoksigenaz geni ALOX12B, ALOXE'dir (22,23).