ALOX12

ALOX12

A gene on chromosome 17p13.1 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.
References in periodicals archive ?
Among them, 12 pathways were associated with the carcinogenesis process, highlighting the arachidonic acid metabolism, in which five of the differentially expressed genes in OSCC (ALOX12, CYP2E1, CYP2J2, CYP2U1, and PTGIS) act.
The results of protein analysis by ELISA showed that expression of ALOX12 (median: OSCC = 12.09 ng/[micro]L vs.
Thymonin interacted with the inflammation-related targets Alox5, Alox12 TNFRSF1A, and PDGFRB.
Others are involved in the metabolism of arachidonic acid, such as ALOX12, PLA2G10, PLA2G4B, CYP1B1, and CYP2A6.
(i) IL8: interleukin 8; (ii) VEGFA: vascular endothelial growth factor A; (iii) SOD1: superoxide dismutase 1, soluble; (iv) SOD2: superoxide dismutase 2, mitochondrial; (v) NCF2: neutrophil cytosolic factor 2; (vi) NQO1: NAD(P)H dehydrogenase, quinone 1; (vii) ALOX12: arachidonate 12-lipoxygenase, 12S type.
Disease or Function p-Value Molecules # Mole Annotation cules Mood disorders 3.73E--04 ADRA2B, ALOX12, AQP4, CA9, 22 CACNB2, CCKBR, CHRNA1, CHR NB4, CHRNG, DDC, ESR1, GRIA3, GRIK2, GRIN1, KCNK2, MTNR 1A, MYOM1, NCAM1, NDUFS7, PDE11A, SCN11A, SCN2B Depressive disorder 7.90E--04 ADRA2B, AQP4, CACNB2, 14 CCKBR, CHRNA1, CHRNB4, CHRNG, ESR1, GRIA3, GRIN1, KCNK2, MYOM1, NCAM1, PDE11A Table 3 Effect of Rhodiola on genes involved in depression ([section]).
The contribution of cofactors is further exemplified by the case of Alox12, a granular layer protein important for epidermal barrier formation, which is induced by [DELTA]Np63[alpha] only in differentiating keratinocytes [68].
Koster, "P63 directly induces expression of Alox12, a regulator of epidermal barrier formation," Experimental Dermatology, vol.
Third, using a candidate-gene approach based on a literature search for air pollution associated genes we investigated separately a set of 739 CpGs in 38 antioxidant and inflammatory genes (TGFB1, ARG1, ARG2, GSTM1, GSTP1, NQO1, SOD2, GPX1, HMOX-1, CAT, GSTT1, EPHX1, NOS2, TNF, NFE2L2, GSS, GPX7, GPX2, GSTZ1, ALB, SRXN1, NOX5, ALOX12, NCF2, AOX1, MPV17, SIRT2, MBL2, OXSR1, OXR1, NUDT1, DUOX2, EPX, PXDNL, PXDN, MPO, LPO, TPO) (Carlsten and Melen 2012; Chen et al.
Arachidonate 15-Lipoxygenases (ALOX15) and Arachidonate 12-Lipoxygenases (ALOX12), members of the LOX family that oxygenate free polyenoic fatty acids, were two key enzymes to synthesize LXA4 [32].